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Abstract：
Eosinophilic gastrointestinal disease (EGID) is divided into eosinophilic esophagitis (EoE) and non-eosinophilic esophagitis eosinophilic gastrointestinal disease (non-EoE-EGID) based on the involved gastrointestinal segments. Reports regarding non-EoE-EGID are limited, in part because of its rarity. The present study was performed to review non-EoE-EGID, including its pathogenesis, diagnosis, treatment, and prognosis. Additionally, details regarding 28 cases of non-EoE-EGID recently diagnosed at our Japanese tertial medical center are presented and compared with 20 EoE cases diagnosed during the same period at the same medical center. Comparisons of the two groups clarified differences regarding age- and gender-dependent prevalence between the two conditions, and also showed that systemic involvement and disease severity were greater in the non-EoE-EGID patients. Notably, diagnosis of non-EoE-EGID is difficult because of its lack of specific or characteristic symptoms and endoscopic findings. The clinical characteristics of EoE and non-EoE-EGID differ in many ways, while they also share several genetic, clinical, laboratory, and histopathological features.
摘要：
嗜酸粒细胞性胃肠道疾病（EGID）根据所涉及的胃肠道节段分为嗜酸粒细胞性食管炎（EoE）和非嗜酸粒细胞性食管炎嗜酸粒细胞性胃肠道疾病（非EoE-EGID）。关于非EoE-EGID的报告有限，部分原因是它的稀有性。本研究旨在审查非EoE-EGID，包括其发病机理,诊断,治疗,和预后。此外,我们介绍了最近在我们的日本医疗中心诊断的28例非EoE-EGID病例的详细信息,并将其与同期在同一医疗中心诊断的20例EoE病例进行了比较.两组的比较阐明了两种情况之间年龄和性别依赖性患病率的差异，并且还显示非EoE-EGID患者的全身受累和疾病严重程度更大.值得注意的是,非EoE-EGID的诊断很困难,因为它缺乏特异性或特征性症状和内镜检查结果.EoE和非EoE-EGID的临床特征在许多方面不同，虽然它们也有几种遗传，临床,实验室,和组织病理学特征。
