PDF(Pubmed)
Abstract：
Polycyclic aromatic hydrocarbons (PAHs) have been reported to cause oxidative stress in metabolic processes. This study aimed to evaluate the relationship between exposure to PAHs, including benzo[a]pyrene (BaP) and 1-nitropyrene (1-NP), in the atmosphere and oxidative stress levels in the human body. This study included 44 Korean adults who lived in Cheongju, Republic of Korea. Atmospheric BaP and 1-NP concentrations and urinary 6-hydroxy-1-nitropyrene (6-OHNP), N-acetyl-1-aminopyrene (1-NAAP), and 1-hydroxypyrene (1-OHP) concentrations were measured. The oxidative stress level was assessed by measuring urinary thiobarbituric acid-reactive substances (TBARS) and 8-hydroxydeoxyguanosine (8-OHdG) concentrations. Urinary TBARS and 6-OHNP concentrations significantly differed between winter and summer. BaP exposure was significantly associated with urinary 8-OHdG concentrations in summer. However, atmospheric 1-NP did not show a significant correlation with oxidative stress marker concentrations. Urinary 1-NAAP concentration was a significant determinant for urinary 8-OHdG concentration in summer. Oxidative stress in the body increases in proportion to inhalation exposure to BaP, and more 8-OHdG is produced in the body as the amount of 1-NP, which is metabolized to 1-AP or 1-NAAP, increases.
摘要：
据报道，多环芳烃（PAHs）在代谢过程中会引起氧化应激。本研究旨在评估PAHs暴露与PAHs，包括苯并[a]芘（BaP）和1-硝基芘（1-NP），在大气和人体内的氧化应激水平。这项研究包括居住在清州的44名韩国成年人，大韩民国。大气BaP和1-NP浓度以及尿液中的6-羟基-1-硝基芘（6-OHNP），N-乙酰基-1-氨基芘(1-NAAP),测量1-羟基芘(1-OHP)浓度。通过测量尿硫代巴比妥酸反应性物质（TBARS）和8-羟基脱氧鸟苷（8-OHdG）浓度来评估氧化应激水平。冬季和夏季的尿TBARS和6-OHNP浓度显着不同。BaP暴露与夏季尿8-OHdG浓度显着相关。然而,大气中的1-NP与氧化应激标志物浓度没有显着相关性.夏季尿1-NAAP浓度是尿8-OHdG浓度的重要决定因素。体内的氧化应激与吸入BaP成比例增加，在体内产生更多的8-OHdG作为1-NP的量，代谢为1-AP或1-NAAP，增加。
