PDF(Pubmed)
Abstract：
Concurrent infections caused by multiple fungal pathogens in immunocompromised patients can pose diagnostic and treatment challenges. Here, we presented the first reported case in Taiwan of an AIDS patient who had concurrent infection with Cryptococcus neoformans meningitis and Talaromyces amestolkiae lymphadenopathy. The patient presented with an enlarged inguinal lymph node and was diagnosed with T. amestolkiae lymphadenitis. The species T. amestolkiae was identified using DNA sequencing, which had the capability of differentiating it from other Talaromyces species. The patient was discharged from the hospital following treatment with amphotericin B and subsequent administration of voriconazole. This case highlights the importance of maintaining a suspicion of co-infections and utilizing appropriate diagnostic tools, such as DNA sequencing, to identify possible pathogens. Further studies are needed to determine the optimal treatment for T. amestolkiae and other co-infecting fungal pathogens.
摘要：
免疫功能低下患者中由多种真菌病原体引起的并发感染可能会带来诊断和治疗挑战。这里,我们介绍了台湾首例报告的1例艾滋病患者,该患者并发感染新型隐球菌性脑膜炎和amestolkiae淋巴结病.该患者出现腹股沟淋巴结肿大，并被诊断为T.amestolkiae淋巴结炎。使用DNA测序鉴定了T.amestolkiae物种，具有将其与其他Talaromyces物种区分开的能力。患者在接受两性霉素B治疗并随后服用伏立康唑后出院。该病例强调了保持对合并感染的怀疑和利用适当的诊断工具的重要性。比如DNA测序，以识别可能的病原体。需要进一步的研究来确定T.amestolkiae和其他共同感染真菌病原体的最佳治疗方法。
