PDF(Pubmed)
Abstract：
Cancer is a common illness with a high mortality. Compared with traditional technologies, biomarker detection, with its low cost and simple operation, has a higher sensitivity and faster speed in the early screening and prognosis of cancer. Therefore, extensive research has focused on the development of biosensors and the construction of sensing interfaces. Molybdenum disulfide (MoS2) is a promising two-dimensional (2D) nanomaterial, whose unique adjustable bandgap shows excellent electronic and optical properties in the construction of biosensor interfaces. It not only has the advantages of a high catalytic activity and low manufacturing costs, but it can also further expand the application of hybrid structures through different functionalization, and it is widely used in various biosensors fields. Herein, we provide a detailed introduction to the structure and synthesis methods of MoS2, and explore the unique properties and advantages/disadvantages exhibited by different structures. Specifically, we focus on the excellent properties and application performance of MoS2 and its composite structures, and discuss the widespread application of MoS2 in cancer biomarkers detection from both electrochemical and optical dimensions. Additionally, with the cross development of emerging technologies, we have also expanded the application of other emerging sensors based on MoS2 for early cancer diagnosis. Finally, we summarized the challenges and prospects of MoS2 in the synthesis, functionalization of composite groups, and applications, and provided some insights into the potential applications of these emerging nanomaterials in a wider range of fields.
摘要：
癌症是一种常见的疾病，死亡率很高。与传统技术相比,生物标志物检测，成本低,操作简单,在癌症的早期筛查和预后中具有更高的敏感性和更快的速度。因此,广泛的研究集中在生物传感器的开发和传感接口的构建上。二硫化钼(MoS2)是一种很有前途的二维(2D)纳米材料,其独特的可调带隙在生物传感器界面的构建中显示出优异的电子和光学性能。它不仅具有催化活性高、制造成本低的优点,但它也可以通过不同的功能化进一步扩大混合结构的应用，广泛应用于各种生物传感器领域。在这里，我们对MoS2的结构和合成方法进行了详细的介绍，并探讨了不同结构所表现出的独特性能和优缺点。具体来说,重点研究MoS2及其复合结构的优异性能和应用性能,并从电化学和光学两个方面讨论了MoS2在癌症生物标志物检测中的广泛应用。此外,随着新兴技术的交叉发展，我们还扩展了基于MoS2的其他新兴传感器在早期癌症诊断中的应用。最后,我们总结了MoS2在合成中的挑战和前景，复合基团的功能化，和应用，并对这些新兴纳米材料在更广泛领域的潜在应用提供了一些见解。
