PDF(Pubmed)
Abstract：
Regulatory T cells (Treg), as members of CD4+ T cells, have garnered extensive attention in the research of tumor progression. Treg cells have the function of inhibiting the immune effector cells, preventing tissue damage, and suppressing inflammation. Under the stimulation of the tumor inflammatory microenvironment (IM), the reprogramming of Treg cells enhances their suppression of immune responses, ultimately promoting tumor immune escape or tumor progression. Reducing the number of Treg cells in the IM or lowering the activity of Treg cells while preventing their reprogramming, can help promote the body\'s anti-tumor immune responses. This review introduces a reprogramming mechanism of Treg cells in the IM; and discusses the regulation of Treg cells on tumor progression. The control of Treg cells and the response to Treg inflammatory reprogramming in tumor immunotherapy are analyzed and countermeasures are proposed. This work will provide a foundation for downregulating the immunosuppressive role of Treg in the inflammatory environment in future tumor immunotherapy.
摘要：
调节性T细胞(Treg),作为CD4+T细胞的成员，在肿瘤进展的研究中引起了广泛的关注。Treg细胞具有抑制免疫效应细胞的功能,防止组织损伤，抑制炎症。在肿瘤炎症微环境（IM）的刺激下，Treg细胞的重编程增强了它们对免疫反应的抑制，最终促进肿瘤免疫逃逸或肿瘤进展。减少IM中Treg细胞的数量或降低Treg细胞的活性，同时防止其重编程，可以帮助促进机体的抗肿瘤免疫反应。本文综述了IM中Treg细胞的重编程机制，并讨论了Treg细胞对肿瘤进展的调控。分析了肿瘤免疫治疗中Treg细胞的控制和对Treg炎症重编程的反应，并提出了对策。这项工作将为未来肿瘤免疫治疗中下调Treg在炎症环境中的免疫抑制作用奠定基础。
