Abstract：
Although there have been significant advances in the treatment of heart failure in recent years, chronic heart failure remains a leading cause of cardiovascular disease-related death. Many studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart failure. However, most of the drugs that increase cardiac energy are still in the theoretical or testing stage. Some research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate metabolism. In this review, we summarized the mechanisms by which botanical drugs (the active ingredients/formulas/Chinese patent medicines) improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptors (PPARs) and other related targets. At the same time, some potential protective effects of botanical drugs on myocardium, such as alleviating oxidative stress and dysbiosis signaling, caused by metabolic disorders, were briefly discussed.
摘要：
尽管近年来心力衰竭的治疗取得了重大进展，慢性心力衰竭仍然是心血管疾病相关死亡的主要原因.许多研究发现，靶向心脏代谢重塑对心力衰竭的治疗具有良好的潜力。然而,大多数增加心脏能量的药物仍处于理论或测试阶段。一些研究发现,植物性药物不仅通过多靶点增加心肌能量代谢,而且具有恢复心肌底物代谢平衡的潜力。在这次审查中,我们总结了植物药（活性成分/配方/中成药）通过激活AMP激活的蛋白激酶（AMPK）来提高底物利用率和促进心肌能量代谢的机制，过氧化物酶体增殖物激活受体（PPARs）和其他相关靶标。同时,植物药对心肌的一些潜在保护作用，如缓解氧化应激和生态失调信号，由代谢紊乱引起的，进行了简要讨论。
