PDF(Pubmed)
Abstract：
BACKGROUND: Septic shock is a global public health burden. In addition to the improvement of the level of individual care, the improvement of the overall hospital quality control management is also an essential key aspect of the Surviving Sepsis Campaign (SSC). Using of antibiotics is a cornerstone in the treatment of septic shock, so we conducted this study to investigate the influence of antibiotics and pathogenic bacteria on the mortality of septic shock at the level of overall hospital in China.
METHODS: This was an observational database study in 2021 enrolled the data of 787 hospitals from 31 provinces/municipalities/autonomous regions of Mainland China collected in a survey from January 1, 2021 to December 31, 2021.
RESULTS: The proportion of ICU patients with septic shock was 3.55%, while the patient mortality of septic shock was 23.08%. While carbapenem was the most preferred antibiotic medication used in 459 of the 782 hospitals, the preference for carbapenem did not show significant effect on the patient mortality in the treatment of septic shock (p-value 0.59). Compared with patients with fermenting bacteria as the most common pathogenic bacteria causing septic shock, patients with non-fermenting bacteria had a higher mortality (p-value 0.01).
CONCLUSIONS: Whether using carbapenem as the preferred antibiotic or not, did not show effect on the patient mortality of septic shock. Compared with patients with fermenting bacteria as the most common pathogenic bacteria, patients of septic shock with non-fermenting bacteria had a higher mortality.
METHODS: This was an observational database study in 2021 enrolled the data of 787 hospitals from 31 provinces/municipalities/autonomous regions of Mainland China collected in a survey from January 1, 2021 to December 31, 2021.
RESULTS: The proportion of ICU patients with septic shock was 3.55%, while the patient mortality of septic shock was 23.08%. While carbapenem was the most preferred antibiotic medication used in 459 of the 782 hospitals, the preference for carbapenem did not show significant effect on the patient mortality in the treatment of septic shock (p-value 0.59). Compared with patients with fermenting bacteria as the most common pathogenic bacteria causing septic shock, patients with non-fermenting bacteria had a higher mortality (p-value 0.01).
CONCLUSIONS: Whether using carbapenem as the preferred antibiotic or not, did not show effect on the patient mortality of septic shock. Compared with patients with fermenting bacteria as the most common pathogenic bacteria, patients of septic shock with non-fermenting bacteria had a higher mortality.
摘要：
背景：感染性休克是全球公共卫生负担。除了个人护理水平的提高，改善整体医院质量控制管理也是脓毒症生存运动(SSC)的一个重要方面.抗生素的使用是治疗感染性休克的基石，因此，我们进行了这项研究，以调查抗生素和病原菌对中国整体医院水平的感染性休克死亡率的影响。
方法：这是一项2021年的观察性数据库研究，收集了2021年1月1日至2021年12月31日中国大陆31个省/市/自治区的787家医院的数据。
结果：ICU患者发生感染性休克的比例为3.55%，而脓毒性休克患者的死亡率为23.08%。虽然碳青霉烯是782家医院中459家医院使用的最优选的抗生素药物，在感染性休克治疗中,碳青霉烯类对患者死亡率没有显著影响(p值0.59).与以发酵菌为最常见致病菌引起感染性休克的患者相比,非发酵细菌患者的死亡率较高(p值0.01).
结论：是否使用碳青霉烯作为首选抗生素，未显示对脓毒性休克患者死亡率的影响。与以发酵菌为最常见致病菌的患者相比，非发酵细菌感染性休克患者的死亡率较高.
方法：这是一项2021年的观察性数据库研究，收集了2021年1月1日至2021年12月31日中国大陆31个省/市/自治区的787家医院的数据。
结果：ICU患者发生感染性休克的比例为3.55%，而脓毒性休克患者的死亡率为23.08%。虽然碳青霉烯是782家医院中459家医院使用的最优选的抗生素药物，在感染性休克治疗中,碳青霉烯类对患者死亡率没有显著影响(p值0.59).与以发酵菌为最常见致病菌引起感染性休克的患者相比,非发酵细菌患者的死亡率较高(p值0.01).
结论：是否使用碳青霉烯作为首选抗生素，未显示对脓毒性休克患者死亡率的影响。与以发酵菌为最常见致病菌的患者相比，非发酵细菌感染性休克患者的死亡率较高.
