PDF(Pubmed)
Abstract：
BACKGROUND: Autonomic dysfunctions are prevalent in several cerebellar disorders, but they have not been systematically investigated in spinocerebellar ataxias (SCAs). Studies investigating autonomic deficits in SCAs are fragmented, with each one focusing on different autonomic dysfunctions and different SCA subtypes.
METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we conducted a systematic review of the literature to assess the presence of autonomic dysfunctions in various SCAs. PubMed served as the primary database, and the Rayyan web application was employed for study screening.
RESULTS: We identified 46 articles investigating at least one autonomic function in patients with SCA. The results were analyzed and categorized based on the genetic subtype of SCA, thereby characterizing the specific autonomic deficits associated with each subtype.
CONCLUSIONS: This review confirms the presence of autonomic dysfunctions in various genetic subtypes of SCA, underscoring the cerebellum\'s role in the autonomic nervous system (ANS). It also emphasizes the importance of investigating these functions in clinical practice.
METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we conducted a systematic review of the literature to assess the presence of autonomic dysfunctions in various SCAs. PubMed served as the primary database, and the Rayyan web application was employed for study screening.
RESULTS: We identified 46 articles investigating at least one autonomic function in patients with SCA. The results were analyzed and categorized based on the genetic subtype of SCA, thereby characterizing the specific autonomic deficits associated with each subtype.
CONCLUSIONS: This review confirms the presence of autonomic dysfunctions in various genetic subtypes of SCA, underscoring the cerebellum\'s role in the autonomic nervous system (ANS). It also emphasizes the importance of investigating these functions in clinical practice.
摘要：
背景：自主神经功能障碍在几种小脑疾病中普遍存在，但尚未对脊髓小脑共济失调（SCAs）进行系统研究。调查SCA自主神经缺陷的研究支离破碎，每个人都专注于不同的自主神经功能障碍和不同的SCA亚型。
方法：遵循系统审查和荟萃分析（PRISMA）声明的首选报告项目，我们对文献进行了系统回顾,以评估各种SCA中自主神经功能障碍的存在.PubMed作为主数据库,Rayyan网络应用程序被用于研究筛选。
结果：我们确定了46篇研究SCA患者至少一种自主神经功能的文章。根据SCA的遗传亚型对结果进行了分析和分类，从而表征与每种亚型相关的特定自主神经缺陷。
结论：这篇综述证实了SCA的各种遗传亚型存在自主神经功能障碍，强调小脑在自主神经系统(ANS)中的作用。它还强调了在临床实践中研究这些功能的重要性。
方法：遵循系统审查和荟萃分析（PRISMA）声明的首选报告项目，我们对文献进行了系统回顾,以评估各种SCA中自主神经功能障碍的存在.PubMed作为主数据库,Rayyan网络应用程序被用于研究筛选。
结果：我们确定了46篇研究SCA患者至少一种自主神经功能的文章。根据SCA的遗传亚型对结果进行了分析和分类，从而表征与每种亚型相关的特定自主神经缺陷。
结论：这篇综述证实了SCA的各种遗传亚型存在自主神经功能障碍，强调小脑在自主神经系统(ANS)中的作用。它还强调了在临床实践中研究这些功能的重要性。
