PDF(Pubmed)
Abstract：
Phenobarbital (PB) q12h is the most common treatment recommendation for cats with recurrent epileptic seizures. Medicating cats may be challenging and result in decreased quality of life for both cat and owner. The aim of this retrospective study was to evaluate treatment with oral PB q24h in cats with presumptive idiopathic epilepsy.
Nine cats with presumptive idiopathic epilepsy, receiving oral PB q24h, were included in a retrospective descriptive study.
Seizure remission was achieved in 88% (8/9) of the cats and good seizure control in 12% (1/9) of the cats, treated with a mean dose of oral PB of 2.6 mg/kg q24h (range 1.4-3.8 mg/kg). No cats required an increase of their PB frequency at any time during a mean follow-up period of 3.5 years (range 1.1-8.0 years). No cats displayed side effects or issues with compliance at the last recorded follow-up.
Once-a-day administration of PB for feline epilepsy was safe and resulted in satisfactory seizure control for the nine cats included in this study. The results of this study justify exploring this topic further in larger prospective studies.
Nine cats with presumptive idiopathic epilepsy, receiving oral PB q24h, were included in a retrospective descriptive study.
Seizure remission was achieved in 88% (8/9) of the cats and good seizure control in 12% (1/9) of the cats, treated with a mean dose of oral PB of 2.6 mg/kg q24h (range 1.4-3.8 mg/kg). No cats required an increase of their PB frequency at any time during a mean follow-up period of 3.5 years (range 1.1-8.0 years). No cats displayed side effects or issues with compliance at the last recorded follow-up.
Once-a-day administration of PB for feline epilepsy was safe and resulted in satisfactory seizure control for the nine cats included in this study. The results of this study justify exploring this topic further in larger prospective studies.
摘要：
目的：苯巴比妥（PB）q12h是复发性癫痫发作猫最常见的治疗建议。医疗猫可能是具有挑战性的，并导致猫和主人的生活质量下降。这项回顾性研究的目的是评估口服PBq24h对推定特发性癫痫猫的治疗。
方法：九只猫患有特发性癫痫，接受口服PBq24h，纳入一项回顾性描述性研究。
结果：88％（8/9）的猫实现了癫痫缓解，12％（1/9）的猫实现了良好的癫痫控制，口服PB的平均剂量为2.6mg/kgq24h（范围为1.4-3.8mg/kg）。在平均3.5年（范围1.1-8.0年）的随访期内，没有猫需要在任何时候增加其PB频率。在最后一次记录的随访中，没有猫显示副作用或依从性问题。
结论：每天一次给予PB治疗猫科动物癫痫是安全的，并且对于本研究中的9只猫来说，癫痫发作得到了令人满意的控制。这项研究的结果证明了在更大的前瞻性研究中进一步探索这一主题。
方法：九只猫患有特发性癫痫，接受口服PBq24h，纳入一项回顾性描述性研究。
结果：88％（8/9）的猫实现了癫痫缓解，12％（1/9）的猫实现了良好的癫痫控制，口服PB的平均剂量为2.6mg/kgq24h（范围为1.4-3.8mg/kg）。在平均3.5年（范围1.1-8.0年）的随访期内，没有猫需要在任何时候增加其PB频率。在最后一次记录的随访中，没有猫显示副作用或依从性问题。
结论：每天一次给予PB治疗猫科动物癫痫是安全的，并且对于本研究中的9只猫来说，癫痫发作得到了令人满意的控制。这项研究的结果证明了在更大的前瞻性研究中进一步探索这一主题。
