PDF(Pubmed)
Abstract：
Cultivation and selection of high-quality human embryos are critical for the success of in vitro fertilization-embryo transfer. Time-lapse imaging technology (TLI) provides a stable culture environment for embryos, which can continuously observe and record the development process of early embryos, so that doctors can record embryo development time parameters more accurately. In this study, we review the current observation and research on the main embryo dynamics parameters in TLI and discusses their significance and development for embryo development potential. To analysis and summary, the application and research situation of TLI, we searched PubMed, Web of Science, and China National Knowledge Infrastructure, using TLI, embryo dynamics parameters, embryo development potential as Keywords, cited 50 out of the initial 89 selected literatures and summarized. With comparative analysis and research, we found that the embryo dynamic parameters provided by TLI has been intensively studied in clinical empirical and observational research, extensive experimental data verified its effectiveness and advantages in embryo development potential assessment. TLI provides technical support of embryo dynamic parameters, which may become the quantitative indicators for superior embryos and pregnancy prediction as well. Existing studies have shown that certain kinetic parameters provided by TLI culture can predict embryo implantation, but no parameter has been confirmed as the absolute correlation biological indicators yet. In this review we believe that further research is needed to verify these preliminary and sometimes contradictory results, and explore the predictive significance of various embryo kinetic parameters relying on TLI technology for embryo development potential.
摘要：
高质量人类胚胎的培养和选择对于体外受精-胚胎移植的成功至关重要。延时成像技术(TLI)为胚胎提供了稳定的培养环境,可以连续观察和记录早期胚胎的发育过程，以便医生可以更准确地记录胚胎发育时间参数。在这项研究中,本文综述了TLI中主要胚胎动力学参数的观察和研究现状，并讨论了它们对胚胎发育潜力的意义和发展。分析和总结，TLI的应用和研究现状,我们搜索了PubMed,WebofScience,和中国国家知识基础设施，使用TLI，胚胎动力学参数，胚胎发育潜力作为关键词，在最初的89篇精选文献中引用了50篇，并进行了总结。通过比较分析和研究,我们发现TLI提供的胚胎动力学参数在临床经验和观察研究中得到了深入研究,大量实验数据验证了其在胚胎发育潜力评估中的有效性和优势。TLI为胚胎动力学参数提供技术支持,这也可能成为优越胚胎和妊娠预测的定量指标。现有研究表明，TLI培养提供的某些动力学参数可以预测胚胎植入，但是还没有一个参数被证实是绝对相关的生物学指标。在这篇综述中，我们认为需要进一步的研究来验证这些初步的，有时是矛盾的结果，并探讨各种胚胎动力学参数依托TLI技术对胚胎发育潜能的预测意义。
