UNASSIGNED: BPA was administered by intraperitoneal injection. 4-PBA was administered as an endoplasmic reticulum stress inhibitor by eye drops. Refraction and axial length were measured by refractometer and SD-OCT system. Western blot was performed to detect the expression level of ER stress-related proteins.
UNASSIGNED: BPA-administered mice exhibit axial elongation and myopic refractive shift with endoplasmic reticulum stress in the sclera. BPA administration activated scleral PERK and ATF6 pathways, and 4-PBA eye drops attenuated ER stress response and suppressed myopia progression.
UNASSIGNED: BPA controlled axial elongation during myopia development in a mouse model by inducing scleral ER stress and activation of the PERK/ATF6 pathway. 4-PBA eye drops as ER stress inhibitor suppressed BPA-induced myopia development.
■通过腹膜内注射给予BPA。4-PBA作为内质网应激抑制剂通过滴眼剂给药。通过折射仪和SD-OCT系统测量屈光度和轴向长度。Westernblot检测ER应激相关蛋白的表达水平。
■给予BPA的小鼠在巩膜中表现出轴向伸长和近视屈光移位,并伴有内质网应激。BPA给药激活巩膜PERK和ATF6途径,和4-PBA滴眼液可减弱ER应激反应并抑制近视进展。
■BPA通过诱导巩膜ER应激和PERK/ATF6通路的激活来控制小鼠模型中近视发展过程中的轴向伸长。4-PBA滴眼液作为ER应激抑制剂抑制BPA诱导的近视发展。