PDF(Pubmed)
Abstract：
UNASSIGNED: Ocular axial elongation is one of the features of myopia progression. Endoplasmic reticulum (ER) stress-associated scleral remodeling plays an important role in ocular axial elongation. Bisphenol A (BPA) is one of the most common environmental pollutants and is known to affect various human organs through ER stress. However, whether BPA exerts an effect on scleral remodeling remains unknown. The purpose of this study was to determine the effect of BPA on the development of myopia and scleral ER stress.
UNASSIGNED: BPA was administered by intraperitoneal injection. 4-PBA was administered as an endoplasmic reticulum stress inhibitor by eye drops. Refraction and axial length were measured by refractometer and SD-OCT system. Western blot was performed to detect the expression level of ER stress-related proteins.
UNASSIGNED: BPA-administered mice exhibit axial elongation and myopic refractive shift with endoplasmic reticulum stress in the sclera. BPA administration activated scleral PERK and ATF6 pathways, and 4-PBA eye drops attenuated ER stress response and suppressed myopia progression.
UNASSIGNED: BPA controlled axial elongation during myopia development in a mouse model by inducing scleral ER stress and activation of the PERK/ATF6 pathway. 4-PBA eye drops as ER stress inhibitor suppressed BPA-induced myopia development.
UNASSIGNED: BPA was administered by intraperitoneal injection. 4-PBA was administered as an endoplasmic reticulum stress inhibitor by eye drops. Refraction and axial length were measured by refractometer and SD-OCT system. Western blot was performed to detect the expression level of ER stress-related proteins.
UNASSIGNED: BPA-administered mice exhibit axial elongation and myopic refractive shift with endoplasmic reticulum stress in the sclera. BPA administration activated scleral PERK and ATF6 pathways, and 4-PBA eye drops attenuated ER stress response and suppressed myopia progression.
UNASSIGNED: BPA controlled axial elongation during myopia development in a mouse model by inducing scleral ER stress and activation of the PERK/ATF6 pathway. 4-PBA eye drops as ER stress inhibitor suppressed BPA-induced myopia development.
摘要：
■眼轴伸长是近视进展的特征之一。内质网（ER）应力相关巩膜重塑在眼轴伸长中起重要作用。双酚A（BPA）是最常见的环境污染物之一，已知通过内质网应激影响人体各种器官。然而,BPA是否对巩膜重塑有影响尚不清楚.这项研究的目的是确定BPA对近视和巩膜内质网应激发展的影响。
■通过腹膜内注射给予BPA。4-PBA作为内质网应激抑制剂通过滴眼剂给药。通过折射仪和SD-OCT系统测量屈光度和轴向长度。Westernblot检测ER应激相关蛋白的表达水平。
■给予BPA的小鼠在巩膜中表现出轴向伸长和近视屈光移位，并伴有内质网应激。BPA给药激活巩膜PERK和ATF6途径，和4-PBA滴眼液可减弱ER应激反应并抑制近视进展。
■BPA通过诱导巩膜ER应激和PERK/ATF6通路的激活来控制小鼠模型中近视发展过程中的轴向伸长。4-PBA滴眼液作为ER应激抑制剂抑制BPA诱导的近视发展。
■通过腹膜内注射给予BPA。4-PBA作为内质网应激抑制剂通过滴眼剂给药。通过折射仪和SD-OCT系统测量屈光度和轴向长度。Westernblot检测ER应激相关蛋白的表达水平。
■给予BPA的小鼠在巩膜中表现出轴向伸长和近视屈光移位，并伴有内质网应激。BPA给药激活巩膜PERK和ATF6途径，和4-PBA滴眼液可减弱ER应激反应并抑制近视进展。
■BPA通过诱导巩膜ER应激和PERK/ATF6通路的激活来控制小鼠模型中近视发展过程中的轴向伸长。4-PBA滴眼液作为ER应激抑制剂抑制BPA诱导的近视发展。
