PDF(Pubmed)
Abstract：
Paracoccidioides sp.-Herpes simplex virus (HSV) co-infection was not reported until now and malabsorption syndrome is a rare complication of the acute/subacute form (AF) of paracoccidioidomycosis (PCM), characterized by life-threatening abnormalities, such as fat and protein loss, lymphopenia, ascites, and intense immunosuppression. A 21-year-old woman presented the PCM AF with intense involvement of the abdominal and intestinal lymphoid organs, which leads to the malabsorption syndrome and severe immunosuppression. This patient developed a fatal-disseminated HSV infection associated with the paracoccidioidal disease. This case demonstrates that, in addition to the antigen-specific immunosuppression, some PCM patients can present a generalized cell-mediated immune depression and endogenous infection of latent microorganisms. On the best of our knowledge, this is the first report of an association between PCM and HSV infection.
摘要：
副球菌。-单纯疱疹病毒（HSV）共感染至今尚未报道，吸收不良综合征是副角菌病（PCM）的急性/亚急性形式（AF）的罕见并发症，以危及生命的异常为特征，比如脂肪和蛋白质的流失,淋巴细胞减少,腹水,和强烈的免疫抑制。一名21岁的妇女表现为PCMAF，腹部和肠道淋巴器官严重受累。导致吸收不良综合征和严重的免疫抑制。该患者出现了与副肌样疾病相关的致命传播的HSV感染。这个案例表明,除了抗原特异性免疫抑制，一些PCM患者可以表现出广泛的细胞介导的免疫抑制和潜伏微生物的内源性感染。据我们所知,这是首次报道PCM和HSV感染之间的相关性.
