Lambert-Eaton Myasthenic Syndrome Complicated by Anti-GABAB Receptor Encephalitis.

Lambert - Eaton 型肌无力综合征并发抗 GABAB 受体脑炎。

• 影响指数: 1.282
• 发表时间: 2024 May 1
• 来源期刊: Intern Med
• DOI: 10.2169/internalmedicine.2569-23
• PMID: 37743510
• 文章类型: Case Reports
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Yamada K,Yaguchi H,Ishikawa K,Tanaka D,Oshima Y,Mizushima K,Uwatoko H,Shirai S,Takahashi-Iwata I,Matsushima M,Tanaka K,Yabe I

关键词: GABAB receptor antibodies; Lambert-Eaton myasthenic syndrome (LEMS); autoimmune encephalitis; central apnea

Mesh: Humans; Lambert-Eaton Myasthenic Syndrome / complications diagnosis immunology; Male; Aged; Receptors, GABA-B / immunology; Autoantibodies / blood cerebrospinal fluid; Encephalitis / complications diagnosis immunology; Small Cell Lung Carcinoma / complications diagnosis

Abstract

A 74-year-old man experienced diplopia, generalized muscle weakness, and acute respiratory failure. He was diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) and treated with immunotherapy, but no improvement was observed, and additional symptoms, including central apnea and hallucinations, appeared. Subsequent serum and cerebrospinal fluid (CSF) analyses confirmed the presence of GABAB receptor antibodies, indicating the coexistence of autoimmune encephalitis. Although there were no findings of malignancy, it is highly likely that occult small-cell lung carcinoma was present. When atypical symptoms occur in patients with LEMS, it is important to consider the possibility of concomitant autoimmune encephalitis.

摘要

一个74岁的男人经历了复视,全身肌肉无力,急性呼吸衰竭.他被诊断出患有Lambert-Eaton肌无力综合征（LEMS），并接受了免疫治疗，但是没有观察到改善，和其他症状，包括中枢呼吸暂停和幻觉,出现了。随后的血清和脑脊液（CSF）分析证实了GABAB受体抗体的存在，表明共存的自身免疫性脑炎。虽然没有恶性肿瘤的发现，隐匿性小细胞肺癌很可能存在。当LEMS患者出现非典型症状时，重要的是要考虑并发自身免疫性脑炎的可能性。