Abstract：
The bacterial divisome is a complex nanomachine that drives cell division and separation. The essentiality of these processes leads to the assumption that proteins with core roles will be strictly conserved across all bacterial genomes. However, recent studies in diverse proteobacteria have revealed considerable variation in the early divisome compared with Escherichia coli. While some proteins are highly conserved, their specific functions and interacting partners vary. Meanwhile, different subphyla use clade-specific proteins with analogous functions. Thus, instead of focusing on gene conservation, we must also explore how key functions are maintained during early division by diverging protein networks. An enhanced awareness of these complex genetic networks will clarify the physical and evolutionary constraints of bacterial division.
摘要：
细菌分裂体是驱动细胞分裂和分离的复杂纳米机器。这些过程的必要性导致假设具有核心作用的蛋白质将在所有细菌基因组中严格保守。然而,最近对各种蛋白细菌的研究表明，与大肠杆菌相比，早期分裂体存在相当大的差异。虽然一些蛋白质是高度保守的，他们的具体功能和互动伙伴各不相同。同时,不同的亚门使用具有类似功能的进化枝特异性蛋白质。因此，而不是专注于基因保护，我们还必须探索在早期分裂过程中如何通过不同的蛋白质网络来维持关键功能。增强对这些复杂遗传网络的认识将阐明细菌分裂的物理和进化约束。
