PDF(Pubmed)
Abstract：
To systematically review the association between traumatic life events (TLE) and dementia risk.
Systematic review and meta-analysis.
APA, PsychINFO, Embase and MEDLINE from their inception to 29.05.21 and updated on 20.04.22.
Original research articles published in peer reviewed journals examining the association between TLE and all cause dementia in individuals aged 60 and over. Two researchers independently assessed the risk of bias using the Newcastle-Ottawa Scale. We conducted a generic inverse variance random effects meta-analysis to provide an overall estimate of TLE impact on dementia risk.
Risk, odds and hazards ratios relating to dementia risk.
Initially, 3,487 studies were retrieved in the search and seven studies were included in the meta-analysis with data being used from 276,570 participants. TLE were associated with increased dementia risk. Trauma in general had a pooled HR of 1.21, (95% CI 1.03, 1.43, P = 0.0001). War/ Holocaust trauma and childhood trauma were also associated with increased dementia risk (HR = 1.28 (95% CI 1.01-1.63, P = 0.02) and HR = 1.76 (95% CI 1.17-2.64, P = 0.007) respectively).
We have found an association between TLE and dementia risk. Future research exploring the dimensions of TLE and individual level factors are needed to better understand the relationship between TLE and dementia.
PROSPERO CRD42021253090.
Systematic review and meta-analysis.
APA, PsychINFO, Embase and MEDLINE from their inception to 29.05.21 and updated on 20.04.22.
Original research articles published in peer reviewed journals examining the association between TLE and all cause dementia in individuals aged 60 and over. Two researchers independently assessed the risk of bias using the Newcastle-Ottawa Scale. We conducted a generic inverse variance random effects meta-analysis to provide an overall estimate of TLE impact on dementia risk.
Risk, odds and hazards ratios relating to dementia risk.
Initially, 3,487 studies were retrieved in the search and seven studies were included in the meta-analysis with data being used from 276,570 participants. TLE were associated with increased dementia risk. Trauma in general had a pooled HR of 1.21, (95% CI 1.03, 1.43, P = 0.0001). War/ Holocaust trauma and childhood trauma were also associated with increased dementia risk (HR = 1.28 (95% CI 1.01-1.63, P = 0.02) and HR = 1.76 (95% CI 1.17-2.64, P = 0.007) respectively).
We have found an association between TLE and dementia risk. Future research exploring the dimensions of TLE and individual level factors are needed to better understand the relationship between TLE and dementia.
PROSPERO CRD42021253090.
摘要：
目的：系统评价创伤生活事件（TLE）与痴呆风险之间的关系。
方法：系统评价和荟萃分析。
方法：APA，心理信息,Embase和MEDLINE从成立到29.05.21，并在20.04.22更新。
方法：发表在同行评审期刊上的原创研究文章，研究了年龄在60岁及以上的个体中TLE与所有痴呆之间的关联。两名研究人员使用纽卡斯尔-渥太华量表独立评估偏倚风险。我们进行了一般的逆方差随机效应荟萃分析，以提供TLE对痴呆风险影响的总体估计。
方法：风险，与痴呆症风险相关的赔率和风险比。
结果：最初，在搜索中检索了3,487项研究，其中7项研究被纳入荟萃分析，数据来自276,570名参与者。TLE与痴呆风险增加相关。创伤总体上具有1.21的合并HR(95%CI1.03,1.43,P=0.0001)。战争/大屠杀创伤和儿童创伤也与痴呆风险增加相关(HR=1.28(95%CI1.01-1.63,P=0.02)和HR=1.76(95%CI1.17-2.64,P=0.007))。
结论：我们发现TLE与痴呆风险之间存在关联。未来的研究需要探索TLE的维度和个体水平因素，以更好地理解TLE与痴呆之间的关系。
背景：PROSPEROCRD42021253090。
方法：系统评价和荟萃分析。
方法：APA，心理信息,Embase和MEDLINE从成立到29.05.21，并在20.04.22更新。
方法：发表在同行评审期刊上的原创研究文章，研究了年龄在60岁及以上的个体中TLE与所有痴呆之间的关联。两名研究人员使用纽卡斯尔-渥太华量表独立评估偏倚风险。我们进行了一般的逆方差随机效应荟萃分析，以提供TLE对痴呆风险影响的总体估计。
方法：风险，与痴呆症风险相关的赔率和风险比。
结果：最初，在搜索中检索了3,487项研究，其中7项研究被纳入荟萃分析，数据来自276,570名参与者。TLE与痴呆风险增加相关。创伤总体上具有1.21的合并HR(95%CI1.03,1.43,P=0.0001)。战争/大屠杀创伤和儿童创伤也与痴呆风险增加相关(HR=1.28(95%CI1.01-1.63,P=0.02)和HR=1.76(95%CI1.17-2.64,P=0.007))。
结论：我们发现TLE与痴呆风险之间存在关联。未来的研究需要探索TLE的维度和个体水平因素，以更好地理解TLE与痴呆之间的关系。
背景：PROSPEROCRD42021253090。
