PDF(Pubmed)
Abstract：
BACKGROUND: Dissecting cellulitis of the scalp (DCS) is a chronic inflammatory skin condition characterized by abscesses, nodules, fistulas, and scarring alopecia. Management of this oftentimes debilitating dermatosis can be challenging due to its recalcitrant nature. There is limited data regarding the efficacy of treatment options for DCS.
OBJECTIVE: The aim of this study was to conduct a systematic review of the literature to explore the efficacy and safety of reported DCS treatments.
METHODS: In October 2022, MEDLINE and EMBASE databases were searched for articles on treatments for DCS. Studies that contained outcome efficacy data for DCS treatments were included. Reviews, conference abstracts, meta-analyses, commentaries, non-relevant articles, and articles with no full-text available were excluded. Data extraction was performed by two independent reviewers.
RESULTS: A total of 110 relevant articles with 417 patients were identified. A majority of studies (86.4%) were case reports or series. Treatment options included systemic antibiotics, oral retinoids, biologics, procedural treatments, combination agents, and topical treatments. Oral retinoids and photodynamic therapy were the most extensively studied medical and procedural interventions, respectively.
CONCLUSIONS: Overall, randomized controlled trials are needed to evaluate various treatment regimens for DCS and provide patients with a robust, evidence-based approach to therapy.
OBJECTIVE: The aim of this study was to conduct a systematic review of the literature to explore the efficacy and safety of reported DCS treatments.
METHODS: In October 2022, MEDLINE and EMBASE databases were searched for articles on treatments for DCS. Studies that contained outcome efficacy data for DCS treatments were included. Reviews, conference abstracts, meta-analyses, commentaries, non-relevant articles, and articles with no full-text available were excluded. Data extraction was performed by two independent reviewers.
RESULTS: A total of 110 relevant articles with 417 patients were identified. A majority of studies (86.4%) were case reports or series. Treatment options included systemic antibiotics, oral retinoids, biologics, procedural treatments, combination agents, and topical treatments. Oral retinoids and photodynamic therapy were the most extensively studied medical and procedural interventions, respectively.
CONCLUSIONS: Overall, randomized controlled trials are needed to evaluate various treatment regimens for DCS and provide patients with a robust, evidence-based approach to therapy.
摘要：
背景：解剖头皮蜂窝织炎（DCS）是一种以脓肿为特征的慢性炎症性皮肤病，结节,瘘管,结疤的脱发.由于其顽固的性质，这种经常使人衰弱的皮肤病的管理可能具有挑战性。关于DCS治疗方案的疗效的数据有限。
目的：本研究的目的是对文献进行系统回顾，以探讨已报道的DCS治疗的有效性和安全性。
方法：2022年10月，搜索了MEDLINE和EMBASE数据库中有关DCS治疗的文章。包括包含DCS治疗结果功效数据的研究。评论,会议摘要，荟萃分析，评论,不相关的文章，没有全文的文章被排除在外。数据提取由两名独立的审阅者进行。
结果：共鉴定出110篇相关文章，其中417例患者。大多数研究（86.4％）是病例报告或系列。治疗选择包括全身性抗生素，口服类维生素A,生物制剂,程序化治疗,组合剂，和局部治疗。口服类维生素A和光动力疗法是研究最广泛的医学和程序干预措施，分别。
结论：总体而言，需要随机对照试验来评估DCS的各种治疗方案，并为患者提供稳健的,基于证据的治疗方法。
目的：本研究的目的是对文献进行系统回顾，以探讨已报道的DCS治疗的有效性和安全性。
方法：2022年10月，搜索了MEDLINE和EMBASE数据库中有关DCS治疗的文章。包括包含DCS治疗结果功效数据的研究。评论,会议摘要，荟萃分析，评论,不相关的文章，没有全文的文章被排除在外。数据提取由两名独立的审阅者进行。
结果：共鉴定出110篇相关文章，其中417例患者。大多数研究（86.4％）是病例报告或系列。治疗选择包括全身性抗生素，口服类维生素A,生物制剂,程序化治疗,组合剂，和局部治疗。口服类维生素A和光动力疗法是研究最广泛的医学和程序干预措施，分别。
结论：总体而言，需要随机对照试验来评估DCS的各种治疗方案，并为患者提供稳健的,基于证据的治疗方法。
