ZNF683 标志着抗 PD - 1 治疗 Richter 综合征后与抗肿瘤免疫相关的 CD8 + T 细胞群。
关键词: Hobit PD-1 Richter transformation ZNF683 checkpoint blockade chronic lymphocytic leukemia immunotherapy single-cell RNA sequencing t cells tox
Mesh : Humans Leukemia, Lymphocytic, Chronic, B-Cell / pathology CD8-Positive T-Lymphocytes Lymphoma, Large B-Cell, Diffuse / drug therapy genetics pathology Gene Expression Regulation Immunotherapy
来 源:
DOI:10.1016/j.ccell.2023.08.013
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