Abstract：
BACKGROUND: Migraine is a neurologic condition characterized by hypersensitivity to auditory, olfactory, visual, and cutaneous stimuli; vomiting and nausea; and severe headache. It is the most frequent headache syndrome in children and can be categorized in chronic and/or episodic. Multiple dietary supplements have been inaugurated for the management of migraine, the most prevalent of which is vitamin D.
BACKGROUND: In recent years, vitamin D deficiency has been a global public health problem, with 30-80% of the worldwide population having vitamin D deficiency. The significant role of vitamin D in neurological disorders is underlined by its key role in the brain function of the central nervous system (CNS). Current approaches in paediatric neurology include nonsteroidal anti-inflammatory drugs (NSAID) for the treatment of paediatric migraine, among others. Vitamin D is one of the dietary factors that has been linked to migraine, however, this association has mostly been examined in the adult population.
OBJECTIVE: The aim of this study is to investigate the association between serum vitamin D and paediatric migraine by conducting a review of existing literature. The main question is described with the PICO format (population, intervention, control, and outcomes), while the assessment of the present research is under the PRISMA guidelines for systematic reviews.
CONCLUSIONS: A systematic review of the literature reveals a remarkable association between vitamin D and migraine presentation in the paediatric population, affecting the frequency and duration of the episodes. That being the case, vitamin D supplementation could potentially improve the quality of life of paediatric patients suffering from migraine headaches.
BACKGROUND: In recent years, vitamin D deficiency has been a global public health problem, with 30-80% of the worldwide population having vitamin D deficiency. The significant role of vitamin D in neurological disorders is underlined by its key role in the brain function of the central nervous system (CNS). Current approaches in paediatric neurology include nonsteroidal anti-inflammatory drugs (NSAID) for the treatment of paediatric migraine, among others. Vitamin D is one of the dietary factors that has been linked to migraine, however, this association has mostly been examined in the adult population.
OBJECTIVE: The aim of this study is to investigate the association between serum vitamin D and paediatric migraine by conducting a review of existing literature. The main question is described with the PICO format (population, intervention, control, and outcomes), while the assessment of the present research is under the PRISMA guidelines for systematic reviews.
CONCLUSIONS: A systematic review of the literature reveals a remarkable association between vitamin D and migraine presentation in the paediatric population, affecting the frequency and duration of the episodes. That being the case, vitamin D supplementation could potentially improve the quality of life of paediatric patients suffering from migraine headaches.
摘要：
背景：偏头痛是一种神经系统疾病，其特征是对听觉过敏，嗅觉,视觉，和皮肤刺激;呕吐和恶心;和严重头痛。它是儿童最常见的头痛综合征，可以分为慢性和/或发作性。多种膳食补充剂已经开始用于偏头痛的管理，其中最普遍的是维生素D。
背景：近年来，维生素D缺乏已成为全球公共卫生问题,全球有30-80%的人患有维生素D缺乏症。维生素D在神经系统疾病中的重要作用由其在中枢神经系统（CNS）的脑功能中的关键作用强调。目前儿科神经病学的方法包括非甾体抗炎药（NSAID）用于治疗儿科偏头痛，在其他人中。维生素D是与偏头痛有关的饮食因素之一，然而,这种关联主要在成年人群中进行了检查。
目的：本研究的目的是通过对现有文献进行综述，探讨血清维生素D与小儿偏头痛之间的关系。主要问题用PICO格式描述(人口，干预，control,和结果)，而对本研究的评估是在PRISMA系统评价指南下进行的。
结论：对文献的系统综述显示，在儿科人群中，维生素D与偏头痛之间存在显著关联。影响发作的频率和持续时间。既然如此，补充维生素D可能会改善患有偏头痛的儿科患者的生活质量.
背景：近年来，维生素D缺乏已成为全球公共卫生问题,全球有30-80%的人患有维生素D缺乏症。维生素D在神经系统疾病中的重要作用由其在中枢神经系统（CNS）的脑功能中的关键作用强调。目前儿科神经病学的方法包括非甾体抗炎药（NSAID）用于治疗儿科偏头痛，在其他人中。维生素D是与偏头痛有关的饮食因素之一，然而,这种关联主要在成年人群中进行了检查。
目的：本研究的目的是通过对现有文献进行综述，探讨血清维生素D与小儿偏头痛之间的关系。主要问题用PICO格式描述(人口，干预，control,和结果)，而对本研究的评估是在PRISMA系统评价指南下进行的。
结论：对文献的系统综述显示，在儿科人群中，维生素D与偏头痛之间存在显著关联。影响发作的频率和持续时间。既然如此，补充维生素D可能会改善患有偏头痛的儿科患者的生活质量.
