PDF(Pubmed)
Abstract：
Although evidence suggests ginsenosides, the primary active and distinctive components of ginseng, have beneficial effects in cisplatin-induced nephrotoxicity, their efficacy and protective mechanisms remain unclear. The aim of the current meta-analysis is to study the effectiveness and mechanisms of ginsenosides in a model of nephrotoxicity induced by cisplatin. Preclinical investigations were conducted in the search of various databases including Medline, Web of Science, Google, CNKI, Embase, and the Wanfang database. 12 studies with 216 animals were included in this review. Stata 15.0 and RevMan 5.3 were used for statistical analyses. The pooled results showed that ginsenosides significantly improved kidney function, and inhibited histological damage. The protective mechanism of ginsenosides is associated with its antioxidative stress, anti-inflammation, anti-apoptosis, and anti-autophagy. The results of our study indicate that ginsenosides have the potential to mitigate nephrotoxicity induced by cisplatin through the modulation of various targets and pathways. Consequently, ginsenosides hold promise as therapeutic agents for the clinical management and prevention of cisplatin-induced nephrotoxicity.
摘要：
尽管有证据表明人参皂苷，人参的主要活性和独特成分，对顺铂诱导的肾毒性有有益作用，其疗效和保护机制尚不清楚.目前的荟萃分析的目的是研究人参皂苷在顺铂诱导的肾毒性模型中的有效性和机制。在搜索包括Medline在内的各种数据库时进行了临床前调查，WebofScience,Google,CNKI,Embase,和万方数据库。这篇综述包括了对216只动物的12项研究。Stata15.0和RevMan5.3用于统计分析。汇总结果显示人参皂苷显著改善肾功能,并抑制组织学损伤。人参皂苷的保护机制与其抗氧化应激有关,抗炎，抗凋亡，和抗自噬。我们的研究结果表明，人参皂苷具有通过调节各种靶标和途径减轻顺铂诱导的肾毒性的潜力。因此,人参皂苷有望作为临床治疗和预防顺铂引起的肾毒性的治疗剂。
