PDF(Pubmed)
Abstract：
Traumatic brain injury (TBI) is a paramount factor in mortality and morbidity. The clinical trials conducted to investigate the efficacy of neuroprotective agents, such as citicoline, as a therapeutic alternative for TBI have presented divergent findings. Therefore, this study aimed to evaluate and compare citicoline\'s effect on the Barthel Index in patients with severe and moderate brain injury.
The study is a randomized clinical trial. Patients in the case group (35 patients) were treated with citicoline and the control group (34 patients) received a placebo. Data were analyzed using SPSS 16 software.
The results showed that changes in the Glasgow Coma Scale, changes in quadriceps muscle force score, Barthel Index score changes, achieving the status without intubation, and spontaneous breathing in patients treated with citicoline were not a statistically significant difference in the two groups (P > 0.05).
Findings revealed that citicoline did not impact the recovery process of severe and moderate TBI patients.
The study is a randomized clinical trial. Patients in the case group (35 patients) were treated with citicoline and the control group (34 patients) received a placebo. Data were analyzed using SPSS 16 software.
The results showed that changes in the Glasgow Coma Scale, changes in quadriceps muscle force score, Barthel Index score changes, achieving the status without intubation, and spontaneous breathing in patients treated with citicoline were not a statistically significant difference in the two groups (P > 0.05).
Findings revealed that citicoline did not impact the recovery process of severe and moderate TBI patients.
摘要：
背景：创伤性脑损伤（TBI）是死亡率和发病率的重要因素。为研究神经保护剂的疗效而进行的临床试验，如胞磷胆碱，作为TBI的治疗替代方案，有不同的发现。因此,本研究旨在评估和比较胞磷胆碱对重度和中度脑损伤患者Barthel指数的影响。
方法：本研究是一项随机临床试验。病例组（35例）患者接受胞二磷胆碱治疗，对照组（34例）接受安慰剂治疗。数据采用SPSS16软件进行分析。
结果：结果显示，格拉斯哥昏迷量表的变化，股四头肌肌力评分的变化，Barthel指数得分变化,达到不插管的状态，胞二磷胆碱治疗组患者自主呼吸与对照组比较差异无统计学意义(P>0.05)。
结论：结果显示胞磷胆碱对重度和中度TBI患者的康复过程没有影响。
方法：本研究是一项随机临床试验。病例组（35例）患者接受胞二磷胆碱治疗，对照组（34例）接受安慰剂治疗。数据采用SPSS16软件进行分析。
结果：结果显示，格拉斯哥昏迷量表的变化，股四头肌肌力评分的变化，Barthel指数得分变化,达到不插管的状态，胞二磷胆碱治疗组患者自主呼吸与对照组比较差异无统计学意义(P>0.05)。
结论：结果显示胞磷胆碱对重度和中度TBI患者的康复过程没有影响。
