PDF(Pubmed)
Abstract：
Background-Pregnancy represents a nutritional challenge, since macro- and micronutrients intake can affect mother\' health and influence negative outcomes. The aim of this retrospective pilot study is to evidence whether the oral supplementation with high molecular weight hyaluronic acid (HMWHA), in association with alpha lipoic acid (ALA), magnesium, vitamin B6 and vitamin D, in pregnant women, could reduce adverse effects, such as PTB, pelvic pain, contraction and hospitalization. Methods-Data were collected from n = 200 women treated daily with oral supplements of 200 mg HMWHA, 100 mg ALA, 450 mg magnesium, 2.6 mg vitamin B6 and 50 mcg vitamin D (treatment group) and from n = 50 women taking with oral supplements of 400 mg magnesium (control group). In both groups, supplementation started from the 7th gestational week until delivery. Results-Oral treatment with HMWHA, in association with ALA, magnesium, vitamin B6 and vitamin D in pregnant women, significantly reduced adverse events, such as PTB (p < 0.01), pelvic pain and contractions (p < 0.0001), miscarriages (p < 0.05) and admission to ER/hospitalization (p < 0.0001) compared with the control group. Conclusions-Despite HMWHA having been poorly used as a food supplement in pregnant women, our results open a reassuring scenario regarding its oral administration during pregnancy.
摘要：
背景-怀孕是一种营养挑战，因为大量和微量营养素的摄入会影响母亲的健康并影响负面结果。这项回顾性试点研究的目的是证明口服补充高分子量透明质酸（HMWHA）与α硫辛酸（ALA）相关，镁，维生素B6和维生素D，在孕妇身上，可以减少不良影响，比如PTB,盆腔疼痛,收缩和住院。方法-数据收集了n=200名每天口服200毫克HMWHA的女性，100毫克ALA，450毫克镁，2.6mg维生素B6和50mcg维生素D（治疗组），n=50女性服用400mg镁（对照组）。在这两组中,从第7孕周开始补充直至分娩。结果-HMWHA口服治疗，与ALA合作，镁，孕妇的维生素B6和维生素D，显著减少不良事件，如PTB(p<0.01)，盆腔疼痛和收缩（p<0.0001），与对照组相比，流产（p<0.05）和入院/住院（p<0.0001）。结论-尽管HMWHA在孕妇中作为食品补充剂的使用很少，我们的结果为妊娠期间口服给药提供了一个令人放心的方案.
