Abstract：
BACKGROUND: Patient-reported outcome measures (PROMs) may have an important role in screening and monitoring for unpleasant symptoms in kidney failure. However, there is still little evidence on the psychometric properties of the measures available to assess physical and psychological symptoms in people on hemodialysis. This gap makes it difficult to decide which measure is the most appropriate for use in clinical practice and research with this population.
OBJECTIVE: This systematic review aimed to critically appraise, compare, and summarize the quality of the measurement properties of PROMs used to assess symptoms in adults on hemodialysis.
METHODS: The protocol for this review was registered in PROSPERO (CRD42023393441). The last database search update was performed on November 25, 2022. The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidelines informed methodological quality assessment, data extraction, analysis, and synthesis.
RESULTS: Twenty-seven primary studies reported the measurement properties of 16 PROMs used to assess physical and psychological symptoms in adults on hemodialysis. Results showed that most measures lacked the necessary psychometric evidence to attest their suitability for this study population, and few underwent rigorous validation procedures. Overall, caveats were found on methodological quality and evidence of content validity and structural validity, and little data was available on responsiveness, measurement error, and cross-cultural validity.
CONCLUSIONS: The current systematic review provides the basis for identifying PROMs with potential utility for assessing symptoms in hemodialysis care. Several recommendations are presented to help guide future research aimed at improving the rigor of validation and/or translation procedures of existing (and future) measures using COSMIN guidelines.
OBJECTIVE: This systematic review aimed to critically appraise, compare, and summarize the quality of the measurement properties of PROMs used to assess symptoms in adults on hemodialysis.
METHODS: The protocol for this review was registered in PROSPERO (CRD42023393441). The last database search update was performed on November 25, 2022. The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidelines informed methodological quality assessment, data extraction, analysis, and synthesis.
RESULTS: Twenty-seven primary studies reported the measurement properties of 16 PROMs used to assess physical and psychological symptoms in adults on hemodialysis. Results showed that most measures lacked the necessary psychometric evidence to attest their suitability for this study population, and few underwent rigorous validation procedures. Overall, caveats were found on methodological quality and evidence of content validity and structural validity, and little data was available on responsiveness, measurement error, and cross-cultural validity.
CONCLUSIONS: The current systematic review provides the basis for identifying PROMs with potential utility for assessing symptoms in hemodialysis care. Several recommendations are presented to help guide future research aimed at improving the rigor of validation and/or translation procedures of existing (and future) measures using COSMIN guidelines.
摘要：
背景：患者报告的结果指标（PROMs）可能在筛选和监测肾衰竭的不愉快症状中发挥重要作用。然而,对血液透析患者的生理和心理症状进行评估的可用措施的心理测量特性，仍然缺乏证据。这种差距使得很难决定哪种措施最适合用于该人群的临床实践和研究。
目的：本系统评价旨在批判性评价，比较,并总结了用于评估成人血液透析症状的PROM测量特性的质量。
方法：本综述的方案在PROSPERO（CRD42023393441）中注册。上一次数据库搜索更新于2022年11月25日进行。基于Consensus的健康测量指标选择标准（COSMIN）指南告知了方法学质量评估，数据提取,分析,和合成。
结果：27项主要研究报告了用于评估成人血液透析患者生理和心理症状的16种PROM的测量特性。结果表明，大多数措施缺乏必要的心理测量证据来证明其适合本研究人群，很少有人经过严格的验证程序。总的来说,在方法学质量和内容效度和结构效度的证据上发现了警告，关于响应性的数据很少，测量误差,和跨文化有效性。
结论：当前的系统评价为确定在血液透析治疗中具有潜在应用价值的PROMs提供了基础。提出了一些建议，以帮助指导未来的研究，旨在提高使用COSMIN指南的现有（和未来）措施的验证和/或翻译程序的严密性。
目的：本系统评价旨在批判性评价，比较,并总结了用于评估成人血液透析症状的PROM测量特性的质量。
方法：本综述的方案在PROSPERO（CRD42023393441）中注册。上一次数据库搜索更新于2022年11月25日进行。基于Consensus的健康测量指标选择标准（COSMIN）指南告知了方法学质量评估，数据提取,分析,和合成。
结果：27项主要研究报告了用于评估成人血液透析患者生理和心理症状的16种PROM的测量特性。结果表明，大多数措施缺乏必要的心理测量证据来证明其适合本研究人群，很少有人经过严格的验证程序。总的来说,在方法学质量和内容效度和结构效度的证据上发现了警告，关于响应性的数据很少，测量误差,和跨文化有效性。
结论：当前的系统评价为确定在血液透析治疗中具有潜在应用价值的PROMs提供了基础。提出了一些建议，以帮助指导未来的研究，旨在提高使用COSMIN指南的现有（和未来）措施的验证和/或翻译程序的严密性。
