PDF(Pubmed)
Abstract：
Non-tuberculosis mycobacteria (NTM) skin infections have become increasingly prevalent in recent years, presenting a unique challenge in clinical management. This review explored the complexities of NTM infections localized to the superficial tissues and provided valuable insights into the optimal therapeutic strategies. The antibiotic selection should base on NTM species and their susceptibility profiles. It is recommended to adopt a comprehensive approach that considers the unique characteristics of superficial tissues to improve treatment effectiveness and reduce the incidence of adverse reactions, infection recurrence, and treatment failure. Infection control measures, patient education, and close monitoring should complement the treatment strategies to achieve favorable outcomes in managing NTM skin infections. Further efforts are warranted to elucidate factors and mechanisms contributing to treatment resistance and relapse. Future research should focus on exploring novel treatment options, innovative drug development/delivery platforms, and precise methodologies for determining therapeutic duration. Longitudinal studies are also needed to assess the long-term safety profiles of the integrated approaches.
摘要：
近年来，非结核分枝杆菌(NTM)皮肤感染越来越普遍，在临床管理中提出了独特的挑战。这篇综述探讨了局限于浅表组织的NTM感染的复杂性，并为最佳治疗策略提供了有价值的见解。抗生素选择应基于NTM物种及其敏感性。建议采取综合考虑浅表组织独特特性的综合方法,以提高治疗效果,降低不良反应发生率,感染复发，治疗失败。感染控制措施,患者教育,密切监测应补充治疗策略，以在管理NTM皮肤感染方面取得良好的结果。需要进一步努力阐明导致治疗抵抗和复发的因素和机制。未来的研究应该集中在探索新的治疗方案上，创新药物开发/交付平台，以及确定治疗持续时间的精确方法。还需要纵向研究来评估综合方法的长期安全性。
