Abstract:
Obesity-induced heart failure (HF) in young people is a serious problem. The treatments for HF have developed in recent years. The following four basic HF drugs have been widely recognized as the \"Fantastic Four\": beta-adrenergic blocking agents, mineralocorticoid receptor antagonists (MRA), sodium glucose transporter 2 inhibitors (SGLT2 inhibitors), and angiotensin receptor neprilysin inhibitors (ARNI). However, the interaction between the heart and blood vessels has not received much attention. The cardio-ankle vascular index (CAVI) is an arterial stiffness index that is unaffected by blood pressure at the time of measurement. A 34-year-old obese man was admitted with dyspnea and edema. His cardiac function was severely impaired, and CAVI was increased. After administration of multidisciplinary HF treatment centered on the \"Fantastic Four\", his cardiac function and CAVI improved dramatically in a short time period. This case suggests the importance of improvement both cardiac and vascular function for the treatment of HF.
摘要:
年轻人的肥胖引起的心力衰竭(HF)是一个严重的问题。近年来,HF的治疗方法已经发展起来。以下四种基本的HF药物被广泛认为是“神奇四侠”:β-肾上腺素能阻断剂,盐皮质激素受体拮抗剂(MRA),钠葡萄糖转运蛋白2抑制剂(SGLT2抑制剂),和血管紧张素受体脑啡肽抑制剂(ARNI)。然而,心脏和血管之间的相互作用没有受到太多关注。心踝血管指数(CAVI)是测量时不受血压影响的动脉硬度指数。一名34岁的肥胖男子因呼吸困难和水肿入院。他的心脏功能严重受损,CAVI增加。在以“神奇四侠”为中心的多学科HF治疗后,他的心功能和CAVI在短时间内显着改善。这种情况表明改善心脏和血管功能对于治疗HF的重要性。