PDF(Pubmed)
Abstract：
Otitis media is a significant contributor to healthcare visits and the prescription of drugs. Its associated complications and consequences pose the primary factors for preventable hearing impairment, especially in developing nations. Chronic suppurative otitis media (CSOM) is prevalent among children globally as one of the commonest chronic infectious diseases during childhood. The subsequent complications and sequelae play a central role in causing avoidable hearing loss, particularly within developing countries. In addition to impaired hearing, this condition can lead to severe health complications, such as issues involving the intracranial region. Despite the involvement of microbial, immunological, and genetic factors as well as Eustachian tube characteristics, in the development of CSOM, there remains a need for further elucidation regarding its pathogenesis. Based on its microorganisms, the treatment of choice will be affected to prevent further complications in the child. The primary approach to treating acute otitis media (AOM) involves effectively addressing ear pain and fever symptoms, while antibiotics are only administered in cases where children experience severe, long-lasting, or frequent infections. Despite the extensive investigation on AOM pathogenesis, research is scarce regarding CSOM. Given that antibiotic resistance and drug-induced ear damage are growing problems and surgery-related complications, it is imperative to devise effective therapeutic interventions against CSOM arises. Therefore, comprehending the host\'s immune function concerning CSOM and identifying how bacteria sidestep these potent responses becomes crucial. Acquiring insight into molecular mechanisms associated with CSOM will enable scientists to formulate innovative treatment approaches to combat this disease, thereby averting hearing loss consequences. The management consists of watchful waiting, primarily for children with chronic effusions and hearing loss.
摘要：
中耳炎是医疗保健访问和药物处方的重要贡献者。其相关的并发症和后果是可预防的听力损害的主要因素，尤其是在发展中国家。慢性化脓性中耳炎(CSOM)是儿童时期最常见的慢性感染性疾病之一,在全球范围内普遍存在。随后的并发症和后遗症在导致可避免的听力损失中起着核心作用。特别是在发展中国家。除了听力受损,这种情况会导致严重的健康并发症，例如涉及颅内区域的问题。尽管微生物参与，免疫学，遗传因素以及咽鼓管特征，在CSOM的发展中，仍需要进一步阐明其发病机制。基于它的微生物，选择的治疗方法将受到影响，以防止儿童出现进一步的并发症。治疗急性中耳炎（AOM）的主要方法包括有效解决耳痛和发烧症状，虽然抗生素仅在儿童经历严重的情况下使用，持久的,或频繁感染。尽管对AOM的发病机制进行了广泛的研究，关于CSOM的研究很少。鉴于抗生素耐药性和药物诱导的耳朵损伤是日益严重的问题和手术相关的并发症，当务之急是设计有效的治疗干预措施来对抗CSOM的出现。因此,理解宿主关于CSOM的免疫功能，并确定细菌如何避开这些有效的反应变得至关重要。深入了解与CSOM相关的分子机制将使科学家能够制定创新的治疗方法来对抗这种疾病，从而避免听力损失的后果。管理包括警惕的等待，主要用于患有慢性积液和听力损失的儿童。
