PDF(Pubmed)
Abstract：
BACKGROUND: Sildenafil is a selective phosphodiesterase type 5 inhibitor used for the treatment of erectile dysfunction and pulmonary hypertension. It is available over the counter in many countries. While there have been a few reports of retinal vascular occlusion following sildenafil consumption, most cases have other comorbidities as risk factors for the disease, and the exact causal role of this drug in these conditions remains unclear.
METHODS: We present the case of a healthy 32-year-old Iranian man who developed combined central retinal vein occlusion and retinal artery occlusion following sildenafil exposure. The patient underwent a hypercoagulative state workup for possible underlying risk factors. Additionally, we conducted a literature search on PubMed using the keywords: retinal vein occlusion AND Sildenafil OR Viagra, retinal artery occlusion AND Sildenafil OR Viagra, retinal vascular occlusion AND Sildenafil OR Viagra. To obtain more objective results in the reviews, we employed an adverse drug reaction possibility algorithm. The patient was found to be otherwise healthy, and ancillary tests were unremarkable. A literature review identified seven reports of retinal vascular occlusion following sildenafil use. In most of these cases, the role of sildenafil was not clearly established. To the best of our knowledge, our case achieved the highest score based on the algorithm compared with previous reports.
CONCLUSIONS: Sildenafil may be associated with severe retinal vascular accidents in otherwise healthy young individuals.
METHODS: We present the case of a healthy 32-year-old Iranian man who developed combined central retinal vein occlusion and retinal artery occlusion following sildenafil exposure. The patient underwent a hypercoagulative state workup for possible underlying risk factors. Additionally, we conducted a literature search on PubMed using the keywords: retinal vein occlusion AND Sildenafil OR Viagra, retinal artery occlusion AND Sildenafil OR Viagra, retinal vascular occlusion AND Sildenafil OR Viagra. To obtain more objective results in the reviews, we employed an adverse drug reaction possibility algorithm. The patient was found to be otherwise healthy, and ancillary tests were unremarkable. A literature review identified seven reports of retinal vascular occlusion following sildenafil use. In most of these cases, the role of sildenafil was not clearly established. To the best of our knowledge, our case achieved the highest score based on the algorithm compared with previous reports.
CONCLUSIONS: Sildenafil may be associated with severe retinal vascular accidents in otherwise healthy young individuals.
摘要：
背景：西地那非是一种选择性5型磷酸二酯酶抑制剂，用于治疗勃起功能障碍和肺动脉高压。在许多国家/地区都可以在柜台上购买。虽然有一些报道称食用西地那非后视网膜血管阻塞，大多数病例有其他合并症作为疾病的危险因素，这种药物在这些疾病中的确切因果作用尚不清楚。
方法：我们介绍了一名健康的32岁伊朗男子的病例，该男子在接触西地那非后出现了视网膜中央静脉阻塞和视网膜动脉阻塞。患者接受了高凝状态检查，以了解可能的潜在危险因素。此外,我们在PubMed上进行了文献检索，使用关键词：视网膜静脉阻塞和西地那非或伟哥，视网膜动脉阻塞和西地那非或伟哥，视网膜血管阻塞和西地那非或伟哥。为了在审查中获得更客观的结果，我们采用了药物不良反应可能性算法.病人被发现健康，辅助测试并不显著。文献综述确定了使用西地那非后视网膜血管阻塞的七例报道。在大多数情况下，西地那非的作用尚未明确。据我们所知,与以前的报告相比,我们的病例在算法基础上获得了最高分.
结论：西地那非可能与原本健康的年轻人的严重视网膜血管意外有关。
方法：我们介绍了一名健康的32岁伊朗男子的病例，该男子在接触西地那非后出现了视网膜中央静脉阻塞和视网膜动脉阻塞。患者接受了高凝状态检查，以了解可能的潜在危险因素。此外,我们在PubMed上进行了文献检索，使用关键词：视网膜静脉阻塞和西地那非或伟哥，视网膜动脉阻塞和西地那非或伟哥，视网膜血管阻塞和西地那非或伟哥。为了在审查中获得更客观的结果，我们采用了药物不良反应可能性算法.病人被发现健康，辅助测试并不显著。文献综述确定了使用西地那非后视网膜血管阻塞的七例报道。在大多数情况下，西地那非的作用尚未明确。据我们所知,与以前的报告相比,我们的病例在算法基础上获得了最高分.
结论：西地那非可能与原本健康的年轻人的严重视网膜血管意外有关。
