PDF(Pubmed)
Abstract：
BACKGROUND: Hepatitis C has been associated with the development of hepatic steatosis, which increases the risk of liver cancer. The microsomal triglyceride transporter protein (MTTP), is a lipid transport protein that mediates lipid metabolism and CD1d antigen presentation. The study aimed to explore the association between MTTP genotype (-493G/T) polymorphism and hepatic steatosis in hepatitis C.
METHODS: The database \"Pubmed, Cochrane library, CNKI, Web of science, Embase and CBM\" were retrieved to identify the literature. The quality of the selected literature was evaluated using the \"the Newcastle-Ottawa Scale\" (NOS). Relevant data was extracted and analyzed using the Stata software. Heterogeneity was expressed by \"Cochran\'s Q and I2\", with I2 ≥ 50% or P < 0.05 indicating high heterogeneity. A random-effects model and subgroup analysis were conducted to identify the sources of heterogeneity. We also used \"Funnel plots\", \"Egger\'s tests\" and \"Begg\'s tests\" to evaluate biases in the literature.
RESULTS: The study found a significant and positive association between liver steatosis and the HCV genotype 3 with a dominant model of the MTTP genotype (-493G/T) (OR = 11.57, 95%CI: 4.467-29.962, P < 0.001). In contrast, no correlation was found between hepatic steatosis and either the recessive, homozygous or heterozygous models (OR = 1.142, P = 0.5; OR = 1.581, P = 0.081; OR = 1.029, P = 0.86). There was no significant publication biases, as measured by the Funnel plot, and the Egger\'s and Begg\'s tests. Finally, sensitivity analysis showed the obtained results are stable.
CONCLUSIONS: Dominant mutations in the T allele of the MTTP genotype (-493G/T) increase susceptibility to hepatic steatosis in patients presenting with the HCV genotype 3.
METHODS: The database \"Pubmed, Cochrane library, CNKI, Web of science, Embase and CBM\" were retrieved to identify the literature. The quality of the selected literature was evaluated using the \"the Newcastle-Ottawa Scale\" (NOS). Relevant data was extracted and analyzed using the Stata software. Heterogeneity was expressed by \"Cochran\'s Q and I2\", with I2 ≥ 50% or P < 0.05 indicating high heterogeneity. A random-effects model and subgroup analysis were conducted to identify the sources of heterogeneity. We also used \"Funnel plots\", \"Egger\'s tests\" and \"Begg\'s tests\" to evaluate biases in the literature.
RESULTS: The study found a significant and positive association between liver steatosis and the HCV genotype 3 with a dominant model of the MTTP genotype (-493G/T) (OR = 11.57, 95%CI: 4.467-29.962, P < 0.001). In contrast, no correlation was found between hepatic steatosis and either the recessive, homozygous or heterozygous models (OR = 1.142, P = 0.5; OR = 1.581, P = 0.081; OR = 1.029, P = 0.86). There was no significant publication biases, as measured by the Funnel plot, and the Egger\'s and Begg\'s tests. Finally, sensitivity analysis showed the obtained results are stable.
CONCLUSIONS: Dominant mutations in the T allele of the MTTP genotype (-493G/T) increase susceptibility to hepatic steatosis in patients presenting with the HCV genotype 3.
摘要：
背景：丙型肝炎与肝性脂肪变性的发展有关，这增加了肝癌的风险。微粒体甘油三酯转运蛋白（MTTP），是介导脂质代谢和CD1d抗原呈递的脂质转运蛋白。本研究旨在探讨MTTP基因型（-493G/T）多态性与丙型肝炎肝脂肪变性之间的关系。
方法：数据库科克伦图书馆,CNKI,WebofScience,检索Embase和CBM“以鉴定文献。使用“纽卡斯尔-渥太华量表”（NOS）评估所选文献的质量。提取相关数据并使用Stata软件进行分析。异质性用“科克伦的Q和I2”表示，I2≥50%或P<0.05表示高度异质性。进行了随机效应模型和亚组分析以确定异质性的来源。我们还使用了“漏斗图”，“Egger的测试”和“Begg的测试”评估文献中的偏见。
结果：研究发现肝脏脂肪变性和HCV基因型3与MTTP基因型（-493G/T）的显性模型之间存在显着正相关（OR=11.57，95CI：4.467-29.962，P<0.001）。相比之下,肝性脂肪变性与隐性，纯合或杂合模型(OR=1.142,P=0.5;OR=1.581,P=0.081;OR=1.029,P=0.86)。没有明显的出版偏见，根据漏斗图的测量，以及Egger和Begg的测试。最后,敏感性分析表明,所得结果稳定。
结论：MTTP基因型（-493G/T）的T等位基因中的显性突变增加了HCV基因型3患者对肝脂肪变性的易感性。
方法：数据库科克伦图书馆,CNKI,WebofScience,检索Embase和CBM“以鉴定文献。使用“纽卡斯尔-渥太华量表”（NOS）评估所选文献的质量。提取相关数据并使用Stata软件进行分析。异质性用“科克伦的Q和I2”表示，I2≥50%或P<0.05表示高度异质性。进行了随机效应模型和亚组分析以确定异质性的来源。我们还使用了“漏斗图”，“Egger的测试”和“Begg的测试”评估文献中的偏见。
结果：研究发现肝脏脂肪变性和HCV基因型3与MTTP基因型（-493G/T）的显性模型之间存在显着正相关（OR=11.57，95CI：4.467-29.962，P<0.001）。相比之下,肝性脂肪变性与隐性，纯合或杂合模型(OR=1.142,P=0.5;OR=1.581,P=0.081;OR=1.029,P=0.86)。没有明显的出版偏见，根据漏斗图的测量，以及Egger和Begg的测试。最后,敏感性分析表明,所得结果稳定。
结论：MTTP基因型（-493G/T）的T等位基因中的显性突变增加了HCV基因型3患者对肝脂肪变性的易感性。
