Abstract：
Miracle fruit (MF) has emerged as a promising option for healthy noncaloric sweeteners due to its sour-to-sweet taste-modifying effects and high antioxidant activity. We aimed to examine the feasibility and acceptability of using MF as a weight-loss strategy for individuals with diabetes or prediabetes. Fifty Korean-American men and women (25 participants each) aged 45-75 years with diabetes or prediabetes were recruited in this study. They participated in a randomized placebo-controlled crossover trial where they took the assigned tablet (either an MF tablet or a placebo-sugar candy) 10 min before consuming food. Using a 9-point hedonic scale, participants assessed the likings of overall, flavor, texture, and aftertaste for green apples, goat cheese, lemonade, pickles, and plain fat-free yogurt before and 10 min after taking the assigned tablet. Additionally, overall liking for meals and calorie intake were assessed during subsequent ad libitum meal sessions. An ANOVA for a crossover design, and independent and paired t-tests were used to compare the outcomes. The results revealed that all postintervention liking values for sour-tasting foods were higher than the respective preintervention liking values for both interventions. However, the MF intervention showed significantly higher pre-post differences in liking for all sour-tasting foods and the overall liking values for breakfast and dinner compared to the placebo intervention (P < 0.001). Furthermore, the MF intervention resulted in a significantly lower calorie intake for each meal than the placebo (P < 0.001). These findings suggest that MF intervention can be considered a viable weight-loss strategy for individuals with diabetes.
摘要：
奇迹水果（MF）已成为健康无热量甜味剂的有希望的选择，因为它具有酸味到甜味的改善作用和高抗氧化活性。我们旨在研究使用MF作为糖尿病或糖尿病前期患者减肥策略的可行性和可接受性。本研究招募了50名年龄在45-75岁之间患有糖尿病或前驱糖尿病的韩裔美国男性和女性（各25名参与者）。他们参加了一项随机的安慰剂对照交叉试验，在食用食物前10分钟服用指定的片剂（MF片剂或安慰剂糖糖）。用9点享乐量表，参与者评估了整体的喜好，风味,纹理,回味青苹果，山羊奶酪,柠檬水,泡菜,和普通的无脂酸奶之前和10分钟后服用指定的片剂。此外,在随后的随意用餐期间,我们评估了对膳食和热量摄入的总体喜好.交叉设计的方差分析，采用独立和配对t检验比较结局.结果表明，所有干预后对酸味食品的喜欢值均高于两种干预措施各自的干预前喜欢值。然而,与安慰剂干预相比,MF干预在所有酸味食物的喜好以及早餐和晚餐的总体喜好值方面显示出较高的前后差异(P<0.001).此外，MF干预导致每餐热量摄入显著低于安慰剂(P<0.001).这些发现表明，MF干预可以被认为是糖尿病患者可行的减肥策略。
