PDF(Pubmed)
Abstract：
Prof. Luiz Rodolpho Travassos, a distinguished Brazilian scientist, was instrumental in fostering an interdisciplinary research approach that seamlessly combined microbiology and oncology. This work has opened new pathways into the understanding of tumorigenesis and aided in the development of innovative therapeutic tools. One significant area of his work has been the exploration of bioactive peptides, many of which were first identified for their antimicrobial properties. These peptides demonstrate promise as potential cancer therapeutics due to their selectivity, cost-effectiveness, ease of synthesis, low antigenicity, and excellent tissue penetration. Prof. Travassos\' pioneering work uncovered on the potential of peptides derived from microbiological sources, such as those obtained using phage display techniques. More importantly, in international cooperation, peptides derived from complementarity-determining regions (CDRs) that showed antimicrobial activity against Candida albicans further showed to be promising tools with cytotoxic properties against cancer cells. Similarly, peptides derived from natural sources, such as the gomesin peptide, not only had shown antimicrobial properties but could treat cutaneous melanoma in experimental models. These therapeutic tools allowed Prof. Travassos and his group to navigate the intricate landscape of factors and pathways that drive cancer development, including persistent proliferative signaling, evasion of tumor suppressor genes, inhibition of programmed cell death, and cellular immortality. This review examines the mechanisms of action of these peptides, aligning them with the universally recognized hallmarks of cancer, and evaluates their potential as drug candidates. It highlights the crucial need for more selective, microbiology-inspired anti-cancer strategies that spare healthy cells, a challenge that current therapies often struggle to address. By offering a comprehensive assessment of Prof. Travassos\' innovative contributions and a detailed discussion on the increasing importance of microbiology-derived peptides, this review presents an informed and robust perspective on the possible future direction of cancer therapy.
摘要：
Prof.LuizRodolphoTravassos,一位杰出的巴西科学家，有助于促进将微生物学和肿瘤学无缝结合的跨学科研究方法。这项工作为了解肿瘤发生开辟了新途径，并有助于开发创新的治疗工具。他工作的一个重要领域是生物活性肽的探索，其中许多首先被确定为其抗菌性能。这些肽由于其选择性而被证明是潜在的癌症治疗药物。成本效益，易于合成，低抗原性，和优秀的组织渗透。Prof.Travassos的开创性工作揭示了来自微生物来源的肽的潜力，例如使用噬菌体展示技术获得的那些。更重要的是,在国际合作中,来自互补决定区（CDR）的肽对白色念珠菌显示出抗菌活性，进一步显示出具有针对癌细胞的细胞毒性特性的有希望的工具。同样，来自天然来源的肽，比如gomesin肽，在实验模型中不仅显示出抗菌特性，而且可以治疗皮肤黑色素瘤。这些治疗工具允许教授。Travassos和他的团队驾驭了驱动癌症发展的因素和途径的复杂景观，包括持续性增殖信号，逃避抑癌基因，抑制程序性细胞死亡，细胞永生。这篇综述探讨了这些肽的作用机制，将它们与公认的癌症标志对齐，并评估其作为候选药物的潜力。它强调了对更具选择性的关键需求，微生物学启发的抗癌策略，使健康细胞备用，当前疗法经常难以应对的挑战。通过提供对教授的全面评估。Travassos的创新贡献和对微生物学衍生肽日益重要的详细讨论，这篇综述对癌症治疗的未来可能方向提出了一个知情和稳健的观点。
