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Abstract：
The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.
摘要：
肿瘤微环境（TME）的复杂性严重阻碍了各种癌症治疗方式的治疗效果。由于缺氧的存在，TME与正常组织不同，低pH值,和免疫抑制特性。调节TME以逆转肿瘤生长平衡被认为是治疗肿瘤的有效方法。最近,聚合物纳米药物已广泛用于癌症治疗，因为它们的合成可以控制，而且它们是高度可修改的，并显示出重塑TME的巨大潜力。在这次审查中,我们概述了各种刺激响应性聚合物纳米药物在调节TME中的应用，旨在为下一代聚合物纳米药物的设计提供见解，促进聚合物纳米药物用于癌症治疗的发展。
