PDF(Pubmed)
Abstract：
Acrokeratosis paraneoplastica, also known as Bazex syndrome, is a relatively understudied yet clinically important dermatological condition that is inextricably associated with squamous cell carcinoma, predominantly of the upper respiratory and gastrointestinal tracts. Manifesting as unique psoriasis-like cutaneous lesions, Bazex syndrome functions as an early warning signal for underlying malignancies, underscoring the urgent need for its timely diagnosis and intervention. Notwithstanding its clinical relevance, the molecular and cellular mechanisms underpinning its pathogenesis are not fully understood. To address these gaps, this comprehensive literature review undertook a meticulous search across reputable databases such as EMBASE, MEDLINE/PubMed, and Web of Science. Our analysis ventures into multiple putative pathogenic pathways, including shifts in Th2 immune responses, aberrant secretion of growth factors, and immunological reactions to tumor-specific antigens. We also detail the clinical phenotypes of Bazex syndrome and their chronological linkage with the corresponding malignancies. Finally, the review evaluates the therapeutic effectiveness of various approaches, including but not limited to targeted cancer treatments, PUVA therapy, and topical corticosteroids. This synthesis aims to arm healthcare providers with a nuanced understanding of Bazex syndrome, facilitating more accurate diagnosis and tailored treatment paradigms.
摘要：
副角膜缘角化病，也被称为Bazex综合征,是一种相对研究不足但临床上重要的皮肤病，与鳞状细胞癌密不可分，主要是上呼吸道和胃肠道。表现为独特的牛皮癣样皮肤病变，Bazex综合征作为潜在恶性肿瘤的早期预警信号，强调迫切需要及时诊断和干预。尽管它具有临床相关性，其发病机制的分子和细胞机制尚不完全清楚。为了弥补这些差距,这篇全面的文献综述对EMBASE等知名数据库进行了细致的搜索，MEDLINE/PubMed,和WebofScience。我们的分析冒险进入多个推定的致病途径，包括Th2免疫反应的变化，生长因子的异常分泌，和对肿瘤特异性抗原的免疫反应。我们还详细介绍了Bazex综合征的临床表型及其与相应恶性肿瘤的时间联系。最后,这篇综述评估了各种方法的治疗效果，包括但不限于靶向癌症治疗，PUVA治疗,和外用皮质类固醇.这一综合旨在武装医疗保健提供者与Bazex综合征的细微差别的理解，促进更准确的诊断和量身定制的治疗范例。
