PDF(Pubmed)
Abstract：
UNASSIGNED: Most data on liver assessment in type 2 diabetes mellitus (T2DM) patients are from retrospective cohorts with selection bias. We aimed at appraising the feasibility, results, and benefits of an outpatient systematic noninvasive screening for metabolic dysfunction-associated fatty liver disease (MAFLD) severity and determinants in T2DM patients.
UNASSIGNED: We conducted a 50-week cross-sectional study enrolling adult T2DM outpatients from a diabetes clinic. An algorithm based on guidelines was applied using simple bioclinical scores and, if applicable, ultrasound and/or elastometry.
UNASSIGNED: Two hundred and thirteen patients were included. Mean age and body mass index were 62 years and 31 kg/m2 and 29% of patients had abnormal transaminase levels. The acceptance rate of additional liver examinations was 92%. The prevalence of MAFLD, advanced fibrosis and cirrhosis was 87%, 11%, and 4%, respectively. More than half of the cases of advanced fibrosis had not been suspected and were detected by this screening. MAFLD was associated with poor glycemic control, elevated transaminases, low HDL-C and the absence of peripheral arterial disease. Advanced fibrosis was linked to high waist circumference and excessive alcohol consumption, which should be interpreted with caution owing to the small number of patients reporting excessive consumption.
UNASSIGNED: Simple bioclinical tools allowed routine triage of T2DM patients for MAFLD severity, with high adherence of high-risk patients to subsequent noninvasive exams.
UNASSIGNED: We conducted a 50-week cross-sectional study enrolling adult T2DM outpatients from a diabetes clinic. An algorithm based on guidelines was applied using simple bioclinical scores and, if applicable, ultrasound and/or elastometry.
UNASSIGNED: Two hundred and thirteen patients were included. Mean age and body mass index were 62 years and 31 kg/m2 and 29% of patients had abnormal transaminase levels. The acceptance rate of additional liver examinations was 92%. The prevalence of MAFLD, advanced fibrosis and cirrhosis was 87%, 11%, and 4%, respectively. More than half of the cases of advanced fibrosis had not been suspected and were detected by this screening. MAFLD was associated with poor glycemic control, elevated transaminases, low HDL-C and the absence of peripheral arterial disease. Advanced fibrosis was linked to high waist circumference and excessive alcohol consumption, which should be interpreted with caution owing to the small number of patients reporting excessive consumption.
UNASSIGNED: Simple bioclinical tools allowed routine triage of T2DM patients for MAFLD severity, with high adherence of high-risk patients to subsequent noninvasive exams.
摘要：
■大多数2型糖尿病（T2DM）患者的肝脏评估数据来自具有选择偏倚的回顾性队列。我们旨在评估可行性，结果，2型糖尿病患者的代谢功能障碍相关脂肪性肝病（MAFLD）严重程度和决定因素的门诊系统无创筛查的益处。
我们进行了一项为期50周的横断面研究，纳入了糖尿病诊所的成年T2DM门诊患者。使用简单的生物临床评分应用基于指南的算法，如果适用，超声和/或弹性测量。
■纳入了两百十三例患者。平均年龄和体重指数为62岁和31kg/m2，29％的患者转氨酶水平异常。额外肝脏检查的接受率为92％。MAFLD的患病率,晚期纤维化和肝硬化为87％，11%,4%,分别。超过一半的晚期纤维化病例没有被怀疑，并且通过该筛查被发现。MAFLD与血糖控制不良相关，转氨酶升高，低HDL-C和没有外周动脉疾病。晚期纤维化与高腰围和过量饮酒有关，由于报告过度消费的患者数量很少，因此应谨慎解释。
■简单的生物临床工具允许对T2DM患者进行MAFLD严重程度的常规分诊，高风险患者对随后的非侵入性检查的依从性高。
我们进行了一项为期50周的横断面研究，纳入了糖尿病诊所的成年T2DM门诊患者。使用简单的生物临床评分应用基于指南的算法，如果适用，超声和/或弹性测量。
■纳入了两百十三例患者。平均年龄和体重指数为62岁和31kg/m2，29％的患者转氨酶水平异常。额外肝脏检查的接受率为92％。MAFLD的患病率,晚期纤维化和肝硬化为87％，11%,4%,分别。超过一半的晚期纤维化病例没有被怀疑，并且通过该筛查被发现。MAFLD与血糖控制不良相关，转氨酶升高，低HDL-C和没有外周动脉疾病。晚期纤维化与高腰围和过量饮酒有关，由于报告过度消费的患者数量很少，因此应谨慎解释。
■简单的生物临床工具允许对T2DM患者进行MAFLD严重程度的常规分诊，高风险患者对随后的非侵入性检查的依从性高。
