PDF(Pubmed)
Abstract：
Asthma is a common pathology worldwide that occurs due to chronic inflammation of the respiratory airways. Persistent pulmonary inflammation leads to low-grade systemic inflammation, influencing blood vessels and triggering coronary artery disease (CAD) events. This review\'s objectives include discussing the susceptible population for CAD, the mechanism underlying CAD creation in asthma patients, the characteristics of asthma, and the influence of anti-asthmatic medications on CAD development. Adult-onset asthma is strongly linked to CAD and stroke. Future research may shed light on these disparities. Atherosclerosis and asthma are linked through both intrinsic and extrinsic pathways, with inflammation being the intrinsic pathway and hypoxia and tachyarrhythmia being the extrinsic pathways. The most probable mechanisms for increased coronary vasospastic angina (CVsA) incidence in asthmatic patients are vascular smooth muscle cell hypercontraction and endothelial dysfunction. Studies have shown a dose-response relationship between asthma control and myocardial infarction (MI) risk, with uncontrolled asthma at the highest risk. Impairment of ventilatory function is a distinct risk factor for lethal MI and cardiovascular death (CVD). The use of beta-2-agonists and chronic oral glucocorticoid therapy in severe asthmatics has been linked to increasing the risk for CAD. However, some studies have shown that the risk of MI among patients with active asthma is not related to the use of asthma medications. Further research is needed to determine the involvement of adult asthma features and their treatments in the development of CAD.
摘要：
哮喘是由于呼吸道的慢性炎症而发生的全球常见病理。持续性肺部炎症导致低度全身炎症，影响血管和引发冠状动脉疾病（CAD）事件。这篇综述的目标包括讨论CAD的易感人群，哮喘患者CAD产生的潜在机制，哮喘的特点，以及抗哮喘药物对CAD发展的影响。成人发作的哮喘与CAD和中风密切相关。未来的研究可能会揭示这些差异。动脉粥样硬化和哮喘通过内在和外在途径联系在一起，炎症是内在途径，缺氧和快速性心律失常是外在途径。哮喘患者冠状动脉血管痉挛性心绞痛（CVsA）发病率增加的最可能机制是血管平滑肌细胞过度收缩和内皮功能障碍。研究表明，哮喘控制与心肌梗死（MI）风险之间存在剂量反应关系，不受控制的哮喘风险最高。通气功能受损是致死性MI和心血管死亡（CVD）的独特危险因素。在严重哮喘患者中使用β-2-激动剂和慢性口服糖皮质激素治疗与增加CAD风险有关。然而,一些研究表明,活动性哮喘患者发生MI的风险与使用哮喘药物无关.需要进一步的研究来确定成人哮喘特征及其治疗在CAD发展中的参与。
