Abstract：
We report a fluorescent dye TM by incorporating the tetraphenylethylene (TPE) and cholesterol components into perylene bisimides (PBI) derivative. Fluorescence emission spectrum shows that the dye has stable red emission and aggregation-induced emission (AIE) characteristics. The incorporation of cholesterol components triggers TM to show induced chirality through supramolecular self-assembly. The cRGD-functionalized nanoparticles were prepared by encapsulating fluorescent dyes with amphiphilic polymer matrix. The functionalized fluorescent organic nanoparticles exhibit excellent biocompatibility, large Stokes\' shift and good photostability, which make them effective fluorescent probes for targeting cancer cells with high fluorescence contrast.
摘要：
我们通过将四苯基乙烯（TPE）和胆固醇成分掺入到亚苯基双酰亚胺（PBI）衍生物中来报告荧光染料TM。荧光发射光谱表明该染料具有稳定的红色发射和聚集诱导发射(AIE)特性。胆固醇组分的掺入触发TM通过超分子自组装显示诱导的手性。通过用两亲性聚合物基质包封荧光染料制备cRGD官能化纳米颗粒。功能化的荧光有机纳米粒子表现出优异的生物相容性,大斯托克斯位移和良好的光稳定性，这使它们成为具有高荧光对比度的靶向癌细胞的有效荧光探针。
