MRI scans from 84 patients with no detectable radiological evidence of brain pathology were retrospectively analyzed. We investigated the association between PCA type (normal vs. fetal) and perfusion pattern (hyperperfused vs. non-hyperperfused) using Fisher\'s exact test.
Hyperperfusion in the medial occipital cortex and thalami was absent in all patients with fPCA, but present in 69% of those with normal PCA. In patients with unilateral fPCA, hyperperfusion was exclusively observed on the side with the normal PCA.
The study suggests a consistent relationship between PCA type and ASL perfusion patterns in the medial occipital cortex and thalami. Further research is warranted to explore the physiological underpinnings of these findings and their potential clinical implications. Understanding this relationship could improve the interpretation of ASL MRI and contribute to a better understanding of pathophysiological mechanisms associated with PCA variants.
方法:回顾性分析84例患者的MRI扫描,这些患者没有可检测到脑部病理的放射学证据。我们调查了PCA类型(正常与胎儿)和灌注模式(超灌注与非超灌注)使用Fisher精确检验。
结果:所有fPCA患者均无枕骨内侧皮质和丘脑过度灌注,但在正常PCA的患者中存在69%。在单侧fPCA患者中,仅在正常PCA一侧观察到过度灌注。
结论:该研究表明枕骨内侧皮质和丘脑的PCA类型和ASL灌注模式之间存在一致的关系。需要进一步的研究来探索这些发现的生理基础及其潜在的临床意义。了解这种关系可以改善ASLMRI的解释,并有助于更好地理解与PCA变异相关的病理生理机制。