Abstract:
Myopathies are a common manifestation of endocrine disorders. Endocrine myopathies are often overlooked while considering differential diagnoses in patients with musculoskeletal symptoms. The hindrance to mobility and the musculoskeletal discomfort owing to these myopathies are important causes of disability and depreciated quality of life in these patients. Endocrine myopathies occur due to the effects of endogenous or iatrogenic hormonal imbalance on skeletal muscle protein and glucose metabolism, disrupting the excitation-contraction coupling. Abnormalities of the pituitary, thyroid, parathyroid, adrenal, and gonadal hormones have all been associated with myopathies and musculoskeletal symptoms. Endocrine myopathies can either be the complication of a secondary endocrine disorder or a presenting symptom of a missed underlying disorder. Therefore, an underlying endocrine abnormality must always be excluded in all patients with musculoskeletal symptoms. This review presents a compilation of various endocrine myopathies, their etiopathogenesis, clinical presentation, diagnostic modalities, and treatment protocols.
摘要:
肌病是内分泌失调的常见表现。在考虑有肌肉骨骼症状的患者的鉴别诊断时,通常会忽略内分泌肌病。这些肌病导致的活动障碍和肌肉骨骼不适是这些患者残疾和生活质量下降的重要原因。内分泌肌病的发生是由于内源性或医源性激素失衡对骨骼肌蛋白和葡萄糖代谢的影响,破坏激励-收缩耦合。垂体异常,甲状腺,甲状旁腺,肾上腺,和性腺激素都与肌病和肌肉骨骼症状有关。内分泌肌病可以是继发性内分泌疾病的并发症,也可以是错过的潜在疾病的症状。因此,在所有有肌肉骨骼症状的患者中,必须始终排除潜在的内分泌异常。这篇综述提供了各种内分泌肌病的汇编,它们的病因,临床表现,诊断方式,和治疗方案。