Abstract：
Sickle Cell Disease is an inherited autosomal recessive hemoglobinopathy associated with multiorgan damage. This single gene disorder involves one DNA base pair alteration, producing HbS. The sickle-shaped cells form when deoxygenated in the capillaries. The resulting RBC stasis leads to ischemia and pain, and acute and chronic organ damage. Patients with SCD presenting to a dental office need careful examination to rule out any current infections, neurologic deficits, or other organ involvement before formulating a dental treatment plan to avoid prolonged and complicated procedures. Early intervention and dental anxiety management are key to the dental treatment of patients with SCD.
摘要：
镰状细胞病是一种与多器官损伤相关的遗传性常染色体隐性血红蛋白病。这种单基因疾病涉及一个DNA碱基对的改变，生产HBS。镰状细胞在毛细血管中脱氧时形成。由此产生的红细胞淤滞导致缺血和疼痛，以及急性和慢性器官损伤。到牙科诊所就诊的SCD患者需要仔细检查，以排除任何当前的感染，神经缺陷,在制定牙科治疗计划之前，或其他器官受累，以避免长时间和复杂的程序。早期干预和牙科焦虑管理是SCD患者牙科治疗的关键。
