Abstract：
Autoimmune diseases have specific pathophysiologic mechanisms leading to an increased risk of arterial and venous thrombosis. The risk of venous thromboembolism (VTE) varies according to the type and stage of the disease, and to concomitant treatments. In this review, we revise the most common autoimmune disease such as antiphospholipid syndrome, inflammatory myositis, polymyositis and dermatomyositis, rheumatoid arthritis, sarcoidosis, Sjogren syndrome, autoimmune haemolytic anaemia, systemic lupus erythematosus, systemic sclerosis, vasculitis and inflammatory bowel disease. We also provide an overview of pathophysiology responsible for the risk of VTE in each autoimmune disorder, and report current indications to anticoagulant treatment for primary and secondary prevention of VTE.
摘要：
自身免疫性疾病具有特定的病理生理机制，导致动脉和静脉血栓形成的风险增加。静脉血栓栓塞症（VTE）的风险根据疾病的类型和阶段而有所不同，以及伴随的治疗。在这次审查中,我们修改了最常见的自身免疫性疾病，如抗磷脂综合征，炎性肌炎，多发性肌炎和皮肌炎，类风湿性关节炎,结节病,干燥综合征,自身免疫性溶血性贫血,系统性红斑狼疮,系统性硬化症,血管炎和炎症性肠病。我们还提供了每个自身免疫性疾病中VTE风险的病理生理学概述。并报告目前抗凝治疗用于VTE一级和二级预防的指征。
