Abstract：
The infections associated with implantable medical devices can greatly affect the therapeutic effect and impose a heavy financial burden. Therefore, it is of great significance to develop antimicrobial biomaterials for the prevention and mitigation of healthcare-associated infections. Here, a facile construction of antimicrobial surface via one-step co-deposition of peptide polymer and dopamine is reported. The co-deposition of antimicrobial peptide polymer DLL60 BLG40 with dopamine (DA) on the surface of thermoplastic polyurethane (TPU) provides peptide polymer-modified TPU surface (TPU-DLL60 BLG40 ). The antimicrobial test shows that the TPU-DLL60 BLG40 surfaces of the sheet and the catheter both exhibit potent killing of 99.9% of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). In addition, the TPU-DLL60 BLG40 surface also exhibits excellent biocompatibility. This one-step antimicrobial modification method is fast and efficient, implies promising application in surface antimicrobial modification of implantable biomaterials and medical devices.
摘要：
与可植入医疗装置相关的感染可极大地影响治疗效果并施加沉重的经济负担。因此,开发抗菌生物材料对预防和缓解医疗保健相关感染具有重要意义。这里,我们报道了通过肽聚合物和多巴胺的一步共沉积来构建抗菌表面。抗微生物肽聚合物DLL60BLG40与多巴胺(DA)共沉积在热塑性聚氨酯(TPU)表面上提供了肽聚合物修饰的TPU表面(TPU-DLL60BLG40)。抗菌测试表明，片材和导管的TPU-DLL60BLG40表面均显示出有效杀死99.9％的耐甲氧西林金黄色葡萄球菌（MRSA）和大肠杆菌（E.大肠杆菌）。此外,TPU-DLL60BLG40表面也表现出优异的生物相容性。这种一步法抗菌改性方法快速高效,意味着在可植入生物材料和医疗设备的表面抗菌改性中具有广阔的应用前景。本文受版权保护。保留所有权利。
