Abstract：
The prognostic value of systemic cytokine profiles and inflammatory markers in colorectal cancer were explored by several studies. We want to know more about inflammatory biomarkers in colorectal adenoma and early cancer.
The level of 38 inflammatory markers in the plasma of 112 adenoma patients, 72 Tis-T1 staging of colorectal carcinoma patients, 34 T2-T4 staging of colorectal carcinoma patients and 53 normal subjects were detected and compared.
Eight inflammatory biomarkers (Eotaxin, GCSF, IL-4, IL-5, IL-17E, MCP-1, TNF-α and VEGF-A) have higher plasma concentrations in colorectal adenoma and cancer patients compared with normal participants over 50 years old.
Inflammatory markers may have the prognostic value for colorectal adenoma and early-stage carcinoma.
The level of 38 inflammatory markers in the plasma of 112 adenoma patients, 72 Tis-T1 staging of colorectal carcinoma patients, 34 T2-T4 staging of colorectal carcinoma patients and 53 normal subjects were detected and compared.
Eight inflammatory biomarkers (Eotaxin, GCSF, IL-4, IL-5, IL-17E, MCP-1, TNF-α and VEGF-A) have higher plasma concentrations in colorectal adenoma and cancer patients compared with normal participants over 50 years old.
Inflammatory markers may have the prognostic value for colorectal adenoma and early-stage carcinoma.
摘要：
最近,多项研究探索了人血浆中与结直肠肿瘤相关的炎性生物标志物,并研究了系统性细胞因子谱和炎性标志物在结直肠癌中的预后价值.然而,关于结直肠腺瘤和早期癌症中的炎症生物标志物知之甚少。我们比较了112例腺瘤患者血浆中38种炎症标志物的水平，72Tis'T1分期结直肠癌患者，34例大肠癌患者和53例正常人的T2-T4分期。总之,我们发现八种炎症生物标志物(Eotaxin，GCSF,IL-4,IL-5,IL-17E,MCP-1,TNF-α,与50岁以上的正常参与者相比，VEGF-A）在结直肠腺瘤和癌症患者中的血浆浓度更高，并且可能对结直肠腺瘤和早期癌具有预后价值。
