PDF(Pubmed)
Abstract：
Cervical cancer is one of the most frequent gynecological malignancies in Brazil, and most of the patients require pelvic radiotherapy as part of oncological treatment. Pelvic radiotherapy induces ovarian premature insufficiency in pre-menopausal women. This condition impacts the life quality and increases the risk of osteoporosis, obesity, cardiovascular, and neurodegenerative diseases in the middle and long term. Most of these patients have no access to hormonal replacement therapy. Techniques such as ovarian transposition have questionable results when aiming to preserve ovarian function. In this context, a promising alternative is the implantation of fresh ovarian tissue, outside the radiotherapy field, in the abdominal cavity (orthotopic implantation) or in other sites such as the forearm, breast, or subcutaneous tissue (heterotopic implantation). Here we report a successful case of autologous implantation of fresh ovarian tissue in the inner thigh of a young patient with advanced cervical cancer, who was a candidate for concurrent chemoradiotherapy.
摘要：
宫颈癌是巴西最常见的妇科恶性肿瘤之一，大多数患者需要盆腔放疗作为肿瘤治疗的一部分。盆腔放疗诱发绝经前妇女卵巢功能早衰.这种情况会影响生活质量并增加骨质疏松症的风险，肥胖，心血管,以及中长期的神经退行性疾病。这些患者中的大多数无法获得激素替代疗法。当旨在保护卵巢功能时，诸如卵巢移位之类的技术具有可疑的结果。在这种情况下，一个有希望的选择是植入新鲜的卵巢组织，在放射治疗领域之外，在腹腔（原位植入）或其他部位，如前臂，乳房,或皮下组织（异位植入）。在这里，我们报告了一个成功的案例，在年轻的晚期宫颈癌患者的大腿内侧自体植入新鲜的卵巢组织，他是同步放化疗的候选人。
