UNASSIGNED: In this study, mandibular ORN following radiation secondary to oropharyngeal squamous cell carcinoma was included. OTE with composite engineered tissue containing a mixture of autologous culture expanded dental pulp stem cells (DPSCs), autologous uncultured bone marrow aspiration concentrate (BMAC) and autologous platelet-rich plasma (PRP) loaded in β-tricalcium phosphate (β-TCP) or hydroxyapatite (HA) sponge scaffold was used in the mandibular defect and the surrounding tissues. An assessment of clinical, radiological and functional attributes was done.
UNASSIGNED: A total of six cases with a mean age of 58.6 years were included in the study. We noted significant improvement in the mean post-operative score for pain and mouth opening; functional improvement in eating solid/liquid food, tongue movement, speech and deglutition were observed. The aesthetics was measured with Vancouver score and revealed a significance at P < 0.05; also lip competency and occlusion were noted in all the patients. No major complications were noticed until a mean follow-up of 28 months.
UNASSIGNED: Tissue engineering with a regenerative cocktail of autologous culture expanded DPSCs, autologous uncultured BMAC and autologous PRP loaded in HA or β-TCP utilised in the surgical reconstruction of the mandible is an effective treatment modality in the management of mandibular ORN following irradiation.
■在这项研究中,包括口咽鳞状细胞癌继发放疗后的下颌ORN。OTE与含有自体培养扩增牙髓干细胞(DPSCs)混合物的复合工程组织,自体未培养的骨髓抽吸浓缩物(BMAC)和装载在β-磷酸三钙(β-TCP)或羟基磷灰石(HA)海绵支架中的自体富血小板血浆(PRP)用于下颌骨缺损和周围组织。临床评估,放射学和功能属性完成。
■本研究共纳入6例,平均年龄58.6岁。我们注意到疼痛和张口的平均术后评分显着改善;食用固体/液体食物的功能改善,舌头运动,观察到言语和吞咽。用温哥华评分测量美学,并在P<0.05时显示出显著性;在所有患者中也注意到嘴唇能力和咬合。直到平均随访28个月,均未发现重大并发症。
■使用自体培养扩增的DPSC的再生混合物进行组织工程,自体未培养的BMAC和装载HA或β-TCP的自体PRP在下颌骨的手术重建中使用是治疗下颌骨ORN的有效治疗方式。