PDF(Pubmed)
Abstract：
UNASSIGNED: Osteoradionecrosis (ORN), a non-infectious, necrotic condition of the bone, occurs as a major complication of radiotherapy to the irradiated site. Simple irrigation of the involved bone to partial or complete resection of the involved bones is being employed in its conventional management. Osseous tissue engineering (OTE) provides a new strategy by regenerating bone cells along with biocompatible scaffolds and micromolecules to produce an engineered osseous tissue.
UNASSIGNED: In this study, mandibular ORN following radiation secondary to oropharyngeal squamous cell carcinoma was included. OTE with composite engineered tissue containing a mixture of autologous culture expanded dental pulp stem cells (DPSCs), autologous uncultured bone marrow aspiration concentrate (BMAC) and autologous platelet-rich plasma (PRP) loaded in β-tricalcium phosphate (β-TCP) or hydroxyapatite (HA) sponge scaffold was used in the mandibular defect and the surrounding tissues. An assessment of clinical, radiological and functional attributes was done.
UNASSIGNED: A total of six cases with a mean age of 58.6 years were included in the study. We noted significant improvement in the mean post-operative score for pain and mouth opening; functional improvement in eating solid/liquid food, tongue movement, speech and deglutition were observed. The aesthetics was measured with Vancouver score and revealed a significance at P < 0.05; also lip competency and occlusion were noted in all the patients. No major complications were noticed until a mean follow-up of 28 months.
UNASSIGNED: Tissue engineering with a regenerative cocktail of autologous culture expanded DPSCs, autologous uncultured BMAC and autologous PRP loaded in HA or β-TCP utilised in the surgical reconstruction of the mandible is an effective treatment modality in the management of mandibular ORN following irradiation.
UNASSIGNED: In this study, mandibular ORN following radiation secondary to oropharyngeal squamous cell carcinoma was included. OTE with composite engineered tissue containing a mixture of autologous culture expanded dental pulp stem cells (DPSCs), autologous uncultured bone marrow aspiration concentrate (BMAC) and autologous platelet-rich plasma (PRP) loaded in β-tricalcium phosphate (β-TCP) or hydroxyapatite (HA) sponge scaffold was used in the mandibular defect and the surrounding tissues. An assessment of clinical, radiological and functional attributes was done.
UNASSIGNED: A total of six cases with a mean age of 58.6 years were included in the study. We noted significant improvement in the mean post-operative score for pain and mouth opening; functional improvement in eating solid/liquid food, tongue movement, speech and deglutition were observed. The aesthetics was measured with Vancouver score and revealed a significance at P < 0.05; also lip competency and occlusion were noted in all the patients. No major complications were noticed until a mean follow-up of 28 months.
UNASSIGNED: Tissue engineering with a regenerative cocktail of autologous culture expanded DPSCs, autologous uncultured BMAC and autologous PRP loaded in HA or β-TCP utilised in the surgical reconstruction of the mandible is an effective treatment modality in the management of mandibular ORN following irradiation.
摘要：
■放射性骨坏死（ORN），一个非传染性的，骨头坏死，作为对照射部位进行放射治疗的主要并发症。在其常规管理中，正在采用简单的冲洗所涉及的骨骼以部分或完全切除所涉及的骨骼。骨组织工程（OTE）通过再生骨细胞以及生物相容性支架和微分子来产生工程骨组织，提供了一种新策略。
■在这项研究中，包括口咽鳞状细胞癌继发放疗后的下颌ORN。OTE与含有自体培养扩增牙髓干细胞（DPSCs）混合物的复合工程组织，自体未培养的骨髓抽吸浓缩物（BMAC）和装载在β-磷酸三钙（β-TCP）或羟基磷灰石（HA）海绵支架中的自体富血小板血浆（PRP）用于下颌骨缺损和周围组织。临床评估，放射学和功能属性完成。
■本研究共纳入6例，平均年龄58.6岁。我们注意到疼痛和张口的平均术后评分显着改善；食用固体/液体食物的功能改善，舌头运动,观察到言语和吞咽。用温哥华评分测量美学，并在P<0.05时显示出显著性；在所有患者中也注意到嘴唇能力和咬合。直到平均随访28个月，均未发现重大并发症。
■使用自体培养扩增的DPSC的再生混合物进行组织工程，自体未培养的BMAC和装载HA或β-TCP的自体PRP在下颌骨的手术重建中使用是治疗下颌骨ORN的有效治疗方式。
■在这项研究中，包括口咽鳞状细胞癌继发放疗后的下颌ORN。OTE与含有自体培养扩增牙髓干细胞（DPSCs）混合物的复合工程组织，自体未培养的骨髓抽吸浓缩物（BMAC）和装载在β-磷酸三钙（β-TCP）或羟基磷灰石（HA）海绵支架中的自体富血小板血浆（PRP）用于下颌骨缺损和周围组织。临床评估，放射学和功能属性完成。
■本研究共纳入6例，平均年龄58.6岁。我们注意到疼痛和张口的平均术后评分显着改善；食用固体/液体食物的功能改善，舌头运动,观察到言语和吞咽。用温哥华评分测量美学，并在P<0.05时显示出显著性；在所有患者中也注意到嘴唇能力和咬合。直到平均随访28个月，均未发现重大并发症。
■使用自体培养扩增的DPSC的再生混合物进行组织工程，自体未培养的BMAC和装载HA或β-TCP的自体PRP在下颌骨的手术重建中使用是治疗下颌骨ORN的有效治疗方式。
