Abstract：
BACKGROUND: Early detection and resection of colorectal polyps by routine colonoscopy screening can be effective in reducing the risk of colorectal cancer (CRC).
OBJECTIVE: This study aimed to determine the association between diabetes mellitus (DM) and different types of colorectal polyps in the Chinese population.
METHODS: A retrospective analysis was performed on inpatients admitted to the Gastroenterology Department of our hospital from January to December 2019. Clinical data, and colonoscopy and pathology findings of the subjects were collected. Bivariate analysis was used to assess factors associated with colorectal polyps. Significant variables from the bivariate evaluation were included in a stepwise multivariate logistic regression analysis to recognize independent predictors of neoplastic polyps and high-risk adenomas.
RESULTS: The proportion of patients with DM was significantly higher in patients with neoplastic polyps and high-risk adenomas than in patients without polyps. Age ≥ 50 years, male gender, and a first-degree relative with a history of CRC were independent risk factors for neoplastic polyps and high-risk adenomas, even in non-smokers. An independent risk factor analysis that did not include a family history of CRC showed that age, gender, and alcohol consumption were independent risk factors for neoplastic polyps and high-risk adenomas. DM was an independent risk factor for high-risk adenomas (OR = 2.902, 95% CI = 1.221-6.899; p = 0.016) after adjusting for age, gender, alcohol consumption, and body mass index. Thus, a history of DM significantly increases the risk of high-risk adenomas.
CONCLUSIONS: This study demonstrated that patients with DM, age ≥ 50 years, male gender, alcohol consumption, and a first-degree relative with a history of CRC should undergo regular endoscopic screening and colonic polypectomy.
OBJECTIVE: This study aimed to determine the association between diabetes mellitus (DM) and different types of colorectal polyps in the Chinese population.
METHODS: A retrospective analysis was performed on inpatients admitted to the Gastroenterology Department of our hospital from January to December 2019. Clinical data, and colonoscopy and pathology findings of the subjects were collected. Bivariate analysis was used to assess factors associated with colorectal polyps. Significant variables from the bivariate evaluation were included in a stepwise multivariate logistic regression analysis to recognize independent predictors of neoplastic polyps and high-risk adenomas.
RESULTS: The proportion of patients with DM was significantly higher in patients with neoplastic polyps and high-risk adenomas than in patients without polyps. Age ≥ 50 years, male gender, and a first-degree relative with a history of CRC were independent risk factors for neoplastic polyps and high-risk adenomas, even in non-smokers. An independent risk factor analysis that did not include a family history of CRC showed that age, gender, and alcohol consumption were independent risk factors for neoplastic polyps and high-risk adenomas. DM was an independent risk factor for high-risk adenomas (OR = 2.902, 95% CI = 1.221-6.899; p = 0.016) after adjusting for age, gender, alcohol consumption, and body mass index. Thus, a history of DM significantly increases the risk of high-risk adenomas.
CONCLUSIONS: This study demonstrated that patients with DM, age ≥ 50 years, male gender, alcohol consumption, and a first-degree relative with a history of CRC should undergo regular endoscopic screening and colonic polypectomy.
摘要：
背景：通过常规结肠镜筛查早期发现和切除结直肠息肉可有效降低结直肠癌（CRC）的风险。
目的：本研究旨在确定中国人群中糖尿病（DM）与不同类型结直肠息肉之间的关系。
方法：对2019年1-12月我院消化内科收治的住院患者进行回顾性分析。临床数据,收集受试者的结肠镜检查和病理结果。双变量分析用于评估与结直肠息肉相关的因素。来自双变量评估的重要变量包括在逐步多变量逻辑回归分析中，以识别肿瘤性息肉和高风险腺瘤的独立预测因子。
结果：肿瘤性息肉和高危腺瘤患者中DM患者的比例明显高于无息肉患者。年龄≥50岁，男性,有CRC病史的一级亲属是肿瘤性息肉和高危腺瘤的独立危险因素，即使是不吸烟者。一项不包括CRC家族史的独立危险因素分析显示，年龄，性别,饮酒是肿瘤性息肉和高危腺瘤的独立危险因素。校正年龄后，DM是高危腺瘤的独立危险因素（OR=2.902，95％CI=1.221-6.899；p=0.016）。性别,酒精消费,和体重指数。因此，DM病史显著增加高危腺瘤的风险.
结论：这项研究表明，DM患者，年龄≥50岁，男性,酒精消费,有CRC病史的一级亲属应定期接受内镜筛查和结肠息肉切除术.
目的：本研究旨在确定中国人群中糖尿病（DM）与不同类型结直肠息肉之间的关系。
方法：对2019年1-12月我院消化内科收治的住院患者进行回顾性分析。临床数据,收集受试者的结肠镜检查和病理结果。双变量分析用于评估与结直肠息肉相关的因素。来自双变量评估的重要变量包括在逐步多变量逻辑回归分析中，以识别肿瘤性息肉和高风险腺瘤的独立预测因子。
结果：肿瘤性息肉和高危腺瘤患者中DM患者的比例明显高于无息肉患者。年龄≥50岁，男性,有CRC病史的一级亲属是肿瘤性息肉和高危腺瘤的独立危险因素，即使是不吸烟者。一项不包括CRC家族史的独立危险因素分析显示，年龄，性别,饮酒是肿瘤性息肉和高危腺瘤的独立危险因素。校正年龄后，DM是高危腺瘤的独立危险因素（OR=2.902，95％CI=1.221-6.899；p=0.016）。性别,酒精消费,和体重指数。因此，DM病史显著增加高危腺瘤的风险.
结论：这项研究表明，DM患者，年龄≥50岁，男性,酒精消费,有CRC病史的一级亲属应定期接受内镜筛查和结肠息肉切除术.
