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Abstract：
There are 13 globally recognized rubella virus genotypes of which only 2 (1E and 2B) have been detected recently. The largest percentage of all reported rubella virus sequences come from China and Japan with Africa reporting limited data. In a bid to address the lack of rubella genotype data in Uganda and the World Health Organization Africa region, we sought to characterize rubella viruses retrospectively using sera collected from suspected measles patients that turned out rubella IgM positive.Seven sequences belonging to genotype 2B sub-lineage 2B-L2c were obtained. These sequences clustered with other genotype 2B sequences previously reported from Uganda. None of the other genotypes (1E and 1G) reported from Uganda in the earlier years were detected. In addition, none of the sequences were obtained after the introduction of the measles-rubella containing vaccine. The above highlight the need for continuous rubella virological surveillance to confirm interruption of endemic rubella genotype circulation.
摘要：
有13种全球公认的风疹病毒基因型，其中最近仅检测到2种（1E和2B）。所有报告的风疹病毒序列中最大的百分比来自中国和日本，而非洲报告的数据有限。为了解决乌干达和世界卫生组织非洲地区缺乏风疹基因型数据的问题，我们试图使用从风疹IgM阳性的疑似麻疹患者收集的血清对风疹病毒进行回顾性鉴定.获得了属于基因型2B亚谱系2B-L2c的七个序列。这些序列与先前从乌干达报道的其他基因型2B序列成簇。未检测到早期乌干达报告的其他基因型（1E和1G）。此外,在引入含有麻疹-风疹的疫苗后，没有获得任何序列。以上强调了需要进行持续的风疹病毒学监测，以确认地方性风疹基因型循环的中断。
