Abstract：
OBJECTIVE: Heart failure is defined as a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood. The natriuretic peptide is known to exert its biological action on the kidney, heart, blood vessels, renin-angiotensin system, autonomous nervous system, and central nervous system. The natriuretic peptide-natriuretic receptor system plays an important role in the regulation of blood pressure and body fluid volume through its pleiotropic effects.
RESULTS: The clinical and animal studies suggest that natriuretic peptide-natriuretic receptors are important targets for the treatment of heart failure and other cardiovascular diseases. Even though attempts targeting natriuretic peptide receptors are underway for heart failure treatment, they seem insufficient despite the receptor systems\' potential. This review summarizes natriuretic peptide-natriuretic receptor system\'s physiological actions and potential target for the treatment of heart failure. Natriuretic peptides play multiple roles in different parts of the body, almost all of the activities related to this receptor system appear to have the potential to be harnessed to treat heart failure or symptoms associated with heart failure.
RESULTS: The clinical and animal studies suggest that natriuretic peptide-natriuretic receptors are important targets for the treatment of heart failure and other cardiovascular diseases. Even though attempts targeting natriuretic peptide receptors are underway for heart failure treatment, they seem insufficient despite the receptor systems\' potential. This review summarizes natriuretic peptide-natriuretic receptor system\'s physiological actions and potential target for the treatment of heart failure. Natriuretic peptides play multiple roles in different parts of the body, almost all of the activities related to this receptor system appear to have the potential to be harnessed to treat heart failure or symptoms associated with heart failure.
摘要：
目的：心力衰竭被定义为一种复杂的临床综合征，由心室充盈或血液射血的任何结构或功能损害引起。已知利钠肽对肾脏发挥其生物学作用，心,血管,肾素-血管紧张素系统，自主神经系统,和中枢神经系统。利钠肽-利钠受体系统通过其多效作用在调节血压和体液容量中起重要作用。
结果：临床和动物研究表明，利钠肽-利钠受体是治疗心力衰竭和其他心血管疾病的重要靶点。尽管针对利钠肽受体的心力衰竭治疗尝试正在进行中，尽管受体系统有潜力，但它们似乎不足。本文综述了利钠肽-利钠受体系统的生理作用和治疗心力衰竭的潜在靶点。利钠肽在身体的不同部位发挥多种作用,几乎所有与该受体系统相关的活动似乎都有可能用于治疗心力衰竭或与心力衰竭相关的症状。
结果：临床和动物研究表明，利钠肽-利钠受体是治疗心力衰竭和其他心血管疾病的重要靶点。尽管针对利钠肽受体的心力衰竭治疗尝试正在进行中，尽管受体系统有潜力，但它们似乎不足。本文综述了利钠肽-利钠受体系统的生理作用和治疗心力衰竭的潜在靶点。利钠肽在身体的不同部位发挥多种作用,几乎所有与该受体系统相关的活动似乎都有可能用于治疗心力衰竭或与心力衰竭相关的症状。
