Abstract:
Pulmonary epithelioid hemangioendothelioma (PEH) is a rare tumour of vascular origin with low to intermediate malignancy. Typical radiological finding on CT is multiple small nodules in bilateral lungs, and some will have punctate calcifications and pleural thickening. The diagnosis of PEH is confirmed by histopathological findings and positive immunohistochemistry staining. We report a case of a woman in her 50s with a medical history of lung adenocarcinoma. Later, regular chest CT during a routine cancer follow-up revealed multiple small pulmonary nodules and increased sizes of these nodules on serial images, initially misdiagnosed as multiple lung metastases. The histopathological diagnosis was made on a pulmonary wedge resection. Finally, PEH was diagnosed on the basis of positive immunohistochemical staining for CD31, ERF and TFE3. In the current study, the clinicopathological features and review of the literature were investigated. Our case highlights the importance of a histological diagnosis to avoid misdiagnosis.
摘要:
肺上皮样血管内皮瘤(PEH)是一种罕见的血管起源肿瘤,恶性程度低至中度。典型的CT影像学表现为双肺多发小结节,有些会有点状钙化和胸膜增厚。PEH的诊断通过组织病理学发现和阳性免疫组织化学染色证实。我们报告了一例50多岁的女性,有肺腺癌病史。稍后,常规的胸部CT在常规的癌症随访中发现了多个小的肺结节,并且在连续图像上这些结节的大小增加,最初误诊为多发肺转移。组织病理学诊断是在肺楔形切除术中进行的。最后,根据CD31,ERF和TFE3的免疫组织化学染色阳性诊断PEH。在目前的研究中,研究了临床病理特征和文献综述.我们的病例强调了组织学诊断以避免误诊的重要性。