PDF(Pubmed)
Abstract：
Even though antiretroviral therapy (ART) access for human immunodeficiency virus (HIV)-infected children increased dramatically, anaemia has continued as a challenge regardless of a cluster of differentiation (CD4) count and viral load. Hence, the present study aimed to assess the determinants of iron deficiency anaemia among children living with HIV after the initiation of ART. An institution-based unmatched case-control study was conducted among consecutively selected 712 children on HIV care from 1 September to 30 October 2022 in the Metekel zone. A pre-tested and structured data extraction checklist was used to collect the data. Data were analysed using STATA version 16 software. Binary logistic regression was used to find the association between independent variables and anaemia. The level of statistical significance was declared at a value of P < 0⋅05. A total of 712 HIV-positive children (178 cases and 534 controls) were included in this study, with a completeness rate of 98⋅8 %. In multivariable analysis, variables that have a statistically significant association with anaemia were as follows: CD4 count <350 (Adjusted Odds Ratio [AOR] 2⋅76; 95 % CI 1⋅76, 4⋅34), World Health Organization (WHO) clinical stage III (AOR 7⋅9; 95 % CI 3⋅5, 17⋅91) and stage IV (AOR 7⋅8; 95 % CI 3⋅37, 18⋅1), cotrimoxazole prophylaxis therapy (AOR 0⋅5; 95 % CI 0⋅31, 0⋅8) and mid-upper arm circumference (MUAC) ≤11⋅5 mm (AOR 2⋅1; 95 % CI 1⋅34, 3⋅28). The present study found that CD4 count, WHO clinical stage, cotrimoxazole prophylaxis therapy and MUAC were significantly associated with anaemia in children on ART. Therefore, continuous screening of anaemia and nutritional treatment is essential in these patients.
摘要：
尽管感染人类免疫缺陷病毒（HIV）的儿童获得抗逆转录病毒治疗（ART）的机会急剧增加，无论分化簇（CD4）计数和病毒载量如何，贫血仍然是一个挑战。因此，本研究旨在评估ART开始后HIV感染儿童缺铁性贫血的决定因素.从2022年9月1日至10月30日，在Metekel地区连续选择的712名接受艾滋病毒护理的儿童中进行了一项基于机构的无匹配病例对照研究。使用预先测试和结构化的数据提取清单来收集数据。使用STATA版本16软件分析数据。二元逻辑回归用于发现自变量与贫血之间的关联。统计显著性水平为P<0·05。本研究共纳入712名HIV阳性儿童（178例和534名对照），完成率为98·8%。在多变量分析中，与贫血有统计学意义的变量如下：CD4计数<350(调整后的赔率比[AOR]2·76；95%CI1·76，4·34)，世界卫生组织（WHO）临床III期（AOR7·9；95％CI3·5，17·91）和IV期（AOR7·8；95％CI3·37，18·1），复方新诺明预防治疗（AOR0·5；95％CI0·31，0·8）和中上臂周长（MUAC）≤11·5mm（AOR2·1；95％CI1·34，3·28）。本研究发现,CD4计数,WHO临床分期,复方新诺明预防治疗和MUAC与接受ART的儿童贫血显著相关。因此,对这些患者进行持续的贫血筛查和营养治疗至关重要.
