Abstract：
Carotid plaque instability is a risk factor for ischemic stroke, and changes in serum creatinine are associated with carotid plaque. However, the relationship between serum creatinine and carotid plaque stability is not well explained. This study aimed to interpret this relationship for clinical treatment of carotid plaque.
A total of 4363 subjects aged 29-86 from December 2013 to December 2018 were included in this study. The stability of carotid plaque was determined based on ultrasound echoes and divided into two groups: carotid plaque stable group and carotid plaque unstable group. The relationship between serum creatinine and carotid plaque stability was determined using curve fitting methods as well as logistic regression.
After age stratification, there was an inverted U-shaped curve between the stability of right carotid plaque and serum creatinine in males, When serum creatinine levels were less than 84 μmol/L, the probability of carotid plaque instability gradually increased, and the carotid plaque became stable when creatinine levels were greater than 84 μmol/L. The relationship between left carotid female plaque stability and serum creatinine showed a U-shaped curve. When serum creatinine levels were less than 80 μmol/L, the carotid plaque stability stabilized, and the probability increased when creatitine levels were more than 80 μmol/L, as the carotid plaque instability rose.
There was an inverted U-shaped relationship between the stability of carotid plaque in the right carotid artery and serum creatinine in males, and a U-shaped relationship between the stability of carotid plaque in the left carotid artery and serum creatinine in females.
A total of 4363 subjects aged 29-86 from December 2013 to December 2018 were included in this study. The stability of carotid plaque was determined based on ultrasound echoes and divided into two groups: carotid plaque stable group and carotid plaque unstable group. The relationship between serum creatinine and carotid plaque stability was determined using curve fitting methods as well as logistic regression.
After age stratification, there was an inverted U-shaped curve between the stability of right carotid plaque and serum creatinine in males, When serum creatinine levels were less than 84 μmol/L, the probability of carotid plaque instability gradually increased, and the carotid plaque became stable when creatinine levels were greater than 84 μmol/L. The relationship between left carotid female plaque stability and serum creatinine showed a U-shaped curve. When serum creatinine levels were less than 80 μmol/L, the carotid plaque stability stabilized, and the probability increased when creatitine levels were more than 80 μmol/L, as the carotid plaque instability rose.
There was an inverted U-shaped relationship between the stability of carotid plaque in the right carotid artery and serum creatinine in males, and a U-shaped relationship between the stability of carotid plaque in the left carotid artery and serum creatinine in females.
摘要：
目的：颈动脉斑块不稳定是缺血性卒中的危险因素，血清肌酐的变化与颈动脉斑块有关。然而,血肌酐与颈动脉斑块稳定性之间的关系尚不能很好地解释。本研究旨在解释这种关系,为临床治疗颈动脉斑块提供依据。
方法：2013年12月至2018年12月共4363名29-86岁的受试者纳入本研究。根据超声回波测定颈动脉斑块的稳定性,分为两组:颈动脉斑块稳定组和颈动脉斑块不稳定组。采用曲线拟合和logistic回归分析血清肌酐与颈动脉斑块稳定性的关系。
结果：年龄分层后，男性右颈动脉斑块稳定性与血肌酐呈倒U型曲线,当血清肌酐水平低于84μmol/L时，颈动脉斑块不稳定的概率逐渐增加,当肌酐水平大于84μmol/L时，颈动脉斑块变得稳定。左侧颈动脉女性斑块稳定性与血肌酐呈U型曲线。当血清肌酐低于80μmol/L时,颈动脉斑块稳定性稳定,当creatitine水平超过80μmol/L时，概率增加，随着颈动脉斑块不稳定性的上升。
结论：男性右颈动脉斑块稳定性与血肌酐呈倒U型关系，女性左颈动脉斑块稳定性与血肌酐呈U型关系。
方法：2013年12月至2018年12月共4363名29-86岁的受试者纳入本研究。根据超声回波测定颈动脉斑块的稳定性,分为两组:颈动脉斑块稳定组和颈动脉斑块不稳定组。采用曲线拟合和logistic回归分析血清肌酐与颈动脉斑块稳定性的关系。
结果：年龄分层后，男性右颈动脉斑块稳定性与血肌酐呈倒U型曲线,当血清肌酐水平低于84μmol/L时，颈动脉斑块不稳定的概率逐渐增加,当肌酐水平大于84μmol/L时，颈动脉斑块变得稳定。左侧颈动脉女性斑块稳定性与血肌酐呈U型曲线。当血清肌酐低于80μmol/L时,颈动脉斑块稳定性稳定,当creatitine水平超过80μmol/L时，概率增加，随着颈动脉斑块不稳定性的上升。
结论：男性右颈动脉斑块稳定性与血肌酐呈倒U型关系，女性左颈动脉斑块稳定性与血肌酐呈U型关系。
