PDF(Pubmed)
Abstract：
UNASSIGNED: Environmental exposure is characterized by low concentration, chronic, and complex exposure. Traditional epidemiological studies show limitations in reflecting these characteristics since they usually focus on a single or very limited number of exposure factors at a time. In this study, we adopted the methodology of environment-wide association study (EWAS) to figure out the association of human liver function with various environmentally hazardous substances.
UNASSIGNED: We analyzed 2,961 participants from the Korean National Environmental Health Survey Cycle 4 (2018-2020). Using generalized linear model (GLM) analysis, we analyzed the association of 72 variables with 3 liver function indices (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma glutamyl transferase [GGT]). Finally, we visualized our results with Manhattan plot.
UNASSIGNED: In GLM analysis, perfluorooctanesulfonate were positively associated with ALT (odds ratio [OR]: 2.2; 95% confidence interval [CI]: 1.39-3.46; p adjusted = 0.0147) and perfluorodecanoic acid showed positive association with GGT (OR: 2.73; 95% CI: 1.36-5.5; p adjusted = 0.0256). Plasma mercury showed positive association with GGT (OR: 1.45; 95% CI: 1.14-1.84; p adjusted = 0.0315). Using a plastic container while keeping food in the refrigerator was associated with elevated GGT compared to using a glass container (OR: 1.51; 95% CI: 1.16-1.95; p adjusted = 0.0153). 2-ethyl-5-oxohexyl phthalate, showed a negative trend with all 3 indices, with AST (OR: 0.54; 95% CI: 0.39-0.73; p adjusted = 0.00357), ALT (OR: 0.5; 95% CI: 0.34-0.75; p adjusted = 0.036), GGT (OR: 0.55; 95% CI: 0.4-0.76; p adjusted = 0.00697). Bisphenol S and frequent use of sunblock cream showed negative association with ALT (OR: 0.77; 95% CI: 0.66-0.89), and GGT (OR: 0.25; 95% CI: 0.11-0.55), respectively.
UNASSIGNED: We conducted an exploratory study on environmental exposure and human liver function. By using EWAS methodology, we identified 7 factors that could have potential association with liver function.
UNASSIGNED: We analyzed 2,961 participants from the Korean National Environmental Health Survey Cycle 4 (2018-2020). Using generalized linear model (GLM) analysis, we analyzed the association of 72 variables with 3 liver function indices (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma glutamyl transferase [GGT]). Finally, we visualized our results with Manhattan plot.
UNASSIGNED: In GLM analysis, perfluorooctanesulfonate were positively associated with ALT (odds ratio [OR]: 2.2; 95% confidence interval [CI]: 1.39-3.46; p adjusted = 0.0147) and perfluorodecanoic acid showed positive association with GGT (OR: 2.73; 95% CI: 1.36-5.5; p adjusted = 0.0256). Plasma mercury showed positive association with GGT (OR: 1.45; 95% CI: 1.14-1.84; p adjusted = 0.0315). Using a plastic container while keeping food in the refrigerator was associated with elevated GGT compared to using a glass container (OR: 1.51; 95% CI: 1.16-1.95; p adjusted = 0.0153). 2-ethyl-5-oxohexyl phthalate, showed a negative trend with all 3 indices, with AST (OR: 0.54; 95% CI: 0.39-0.73; p adjusted = 0.00357), ALT (OR: 0.5; 95% CI: 0.34-0.75; p adjusted = 0.036), GGT (OR: 0.55; 95% CI: 0.4-0.76; p adjusted = 0.00697). Bisphenol S and frequent use of sunblock cream showed negative association with ALT (OR: 0.77; 95% CI: 0.66-0.89), and GGT (OR: 0.25; 95% CI: 0.11-0.55), respectively.
UNASSIGNED: We conducted an exploratory study on environmental exposure and human liver function. By using EWAS methodology, we identified 7 factors that could have potential association with liver function.
摘要：
■环境暴露的特点是浓度低，慢性，和复杂的曝光。传统的流行病学研究在反映这些特征方面显示出局限性，因为它们通常一次集中于单个或非常有限数量的暴露因素。在这项研究中,我们采用了环境关联研究(EWAS)的方法,以确定人类肝功能与各种环境有害物质之间的关联.
■我们分析了韩国国家环境卫生调查周期4（2018-2020）的2,961名参与者。使用广义线性模型(GLM)分析，我们分析了72个变量与3个肝功能指标(天冬氨酸转氨酶[AST]，丙氨酸转氨酶[ALT]，和γ谷氨酰转移酶[GGT])。最后,我们用曼哈顿的情节想象我们的结果。
■在GLM分析中，全氟辛烷磺酸与ALT呈正相关(比值比[OR]:2.2;95%置信区间[CI]:1.39~3.46;p校正=0.0147),全氟癸酸与GGT呈正相关(OR:2.73;95%CI:1.36~5.5;p校正=0.0256).血浆汞与GGT呈正相关（OR：1.45；95％CI：1.14-1.84；p调整=0.0315）。与使用玻璃容器相比，使用塑料容器同时将食物保存在冰箱中与GGT升高相关（OR：1.51；95％CI：1.16-1.95；p调整=0.0153）。邻苯二甲酸2-乙基-5-氧代己酯，所有3个指数都显示出负趋势，AST（OR：0.54；95%CI：0.39-0.73；p调整=0.00357），ALT（OR：0.5；95%CI：0.34-0.75；p调整=0.036），GGT（OR：0.55；95%CI：0.4-0.76；p调整=0.00697）。双酚S和经常使用防晒霜与ALT呈负相关（OR：0.77;95％CI：0.66-0.89），和GGT（OR：0.25；95%CI：0.11-0.55），分别。
■我们对环境暴露和人体肝功能进行了探索性研究。通过使用EWAS方法，我们确定了7个可能与肝功能相关的因素.
■我们分析了韩国国家环境卫生调查周期4（2018-2020）的2,961名参与者。使用广义线性模型(GLM)分析，我们分析了72个变量与3个肝功能指标(天冬氨酸转氨酶[AST]，丙氨酸转氨酶[ALT]，和γ谷氨酰转移酶[GGT])。最后,我们用曼哈顿的情节想象我们的结果。
■在GLM分析中，全氟辛烷磺酸与ALT呈正相关(比值比[OR]:2.2;95%置信区间[CI]:1.39~3.46;p校正=0.0147),全氟癸酸与GGT呈正相关(OR:2.73;95%CI:1.36~5.5;p校正=0.0256).血浆汞与GGT呈正相关（OR：1.45；95％CI：1.14-1.84；p调整=0.0315）。与使用玻璃容器相比，使用塑料容器同时将食物保存在冰箱中与GGT升高相关（OR：1.51；95％CI：1.16-1.95；p调整=0.0153）。邻苯二甲酸2-乙基-5-氧代己酯，所有3个指数都显示出负趋势，AST（OR：0.54；95%CI：0.39-0.73；p调整=0.00357），ALT（OR：0.5；95%CI：0.34-0.75；p调整=0.036），GGT（OR：0.55；95%CI：0.4-0.76；p调整=0.00697）。双酚S和经常使用防晒霜与ALT呈负相关（OR：0.77;95％CI：0.66-0.89），和GGT（OR：0.25；95%CI：0.11-0.55），分别。
■我们对环境暴露和人体肝功能进行了探索性研究。通过使用EWAS方法，我们确定了7个可能与肝功能相关的因素.
