UNASSIGNED: We analyzed 2,961 participants from the Korean National Environmental Health Survey Cycle 4 (2018-2020). Using generalized linear model (GLM) analysis, we analyzed the association of 72 variables with 3 liver function indices (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma glutamyl transferase [GGT]). Finally, we visualized our results with Manhattan plot.
UNASSIGNED: In GLM analysis, perfluorooctanesulfonate were positively associated with ALT (odds ratio [OR]: 2.2; 95% confidence interval [CI]: 1.39-3.46; p adjusted = 0.0147) and perfluorodecanoic acid showed positive association with GGT (OR: 2.73; 95% CI: 1.36-5.5; p adjusted = 0.0256). Plasma mercury showed positive association with GGT (OR: 1.45; 95% CI: 1.14-1.84; p adjusted = 0.0315). Using a plastic container while keeping food in the refrigerator was associated with elevated GGT compared to using a glass container (OR: 1.51; 95% CI: 1.16-1.95; p adjusted = 0.0153). 2-ethyl-5-oxohexyl phthalate, showed a negative trend with all 3 indices, with AST (OR: 0.54; 95% CI: 0.39-0.73; p adjusted = 0.00357), ALT (OR: 0.5; 95% CI: 0.34-0.75; p adjusted = 0.036), GGT (OR: 0.55; 95% CI: 0.4-0.76; p adjusted = 0.00697). Bisphenol S and frequent use of sunblock cream showed negative association with ALT (OR: 0.77; 95% CI: 0.66-0.89), and GGT (OR: 0.25; 95% CI: 0.11-0.55), respectively.
UNASSIGNED: We conducted an exploratory study on environmental exposure and human liver function. By using EWAS methodology, we identified 7 factors that could have potential association with liver function.
■我们分析了韩国国家环境卫生调查周期4(2018-2020)的2,961名参与者。使用广义线性模型(GLM)分析,我们分析了72个变量与3个肝功能指标(天冬氨酸转氨酶[AST],丙氨酸转氨酶[ALT],和γ谷氨酰转移酶[GGT])。最后,我们用曼哈顿的情节想象我们的结果。
■在GLM分析中,全氟辛烷磺酸与ALT呈正相关(比值比[OR]:2.2;95%置信区间[CI]:1.39~3.46;p校正=0.0147),全氟癸酸与GGT呈正相关(OR:2.73;95%CI:1.36~5.5;p校正=0.0256).血浆汞与GGT呈正相关(OR:1.45;95%CI:1.14-1.84;p调整=0.0315)。与使用玻璃容器相比,使用塑料容器同时将食物保存在冰箱中与GGT升高相关(OR:1.51;95%CI:1.16-1.95;p调整=0.0153)。邻苯二甲酸2-乙基-5-氧代己酯,所有3个指数都显示出负趋势,AST(OR:0.54;95%CI:0.39-0.73;p调整=0.00357),ALT(OR:0.5;95%CI:0.34-0.75;p调整=0.036),GGT(OR:0.55;95%CI:0.4-0.76;p调整=0.00697)。双酚S和经常使用防晒霜与ALT呈负相关(OR:0.77;95%CI:0.66-0.89),和GGT(OR:0.25;95%CI:0.11-0.55),分别。
■我们对环境暴露和人体肝功能进行了探索性研究。通过使用EWAS方法,我们确定了7个可能与肝功能相关的因素.