PDF(Pubmed)
Abstract：
Inflammatory myopathies are a group of diseases whose common pathway is immune-mediated muscle damage, one of which is polymyositis. The definition of polymyositis is controversial, with proponents advocating a definition based on immunohistochemical and histopathological findings in muscle biopsies, while other proponents advocate a definition based on clinical manifestations and histopathological findings. Polymyositis is a quite rare disease that is clinically characterized by progressive proximal muscle weakness with a symmetric distribution. Within the diagnostic approach, laboratory studies show elevation of sarcoplasmic enzymes; nerve conduction tests are performed, which may aid in distinguishing myopathic causes of weakness from neuropathic disorders; and muscle biopsy is considered the gold standard to diagnose inflammatory myopathy and to distinguish the subclasses. We report the case of a 61-year-old male patient who presented generalized symmetrical weakness, predominantly in the upper extremities, and dysphagia, whose laboratory studies, autoantibodies, and muscle biopsy were confirmatory of this entity.
摘要：
炎症性肌病是一组以免疫介导的肌肉损伤为共同途径的疾病,其中之一是多发性肌炎。多发性肌炎的定义是有争议的，支持者主张基于肌肉活检的免疫组织化学和组织病理学发现的定义，而其他支持者主张基于临床表现和组织病理学发现的定义。多发性肌炎是一种非常罕见的疾病，其临床特征是呈对称分布的进行性近端肌无力。在诊断方法中，实验室研究显示肌浆酶升高；进行神经传导测试，这可能有助于区分肌无力的原因和神经性疾病;肌肉活检被认为是诊断炎症性肌病和区分亚类的金标准。我们报告了一例61岁的男性患者，该患者表现出全身性对称无力，主要在上肢，和吞咽困难,谁的实验室研究，自身抗体,肌肉活检证实了这一实体。
